Evaluation of lipid profile and statin therapy in patients with atrial fibrillation: Real-life data from a tertiary hospital

Abdulrahman Naser; Yucel Uzun; Samet Sayılan; Oya Güven; Merve Demireller; Ahmet Ekmekci

doi:10.19161/etd.1418118

TR EN

Atriyal Fibrilasyonlu Hastalarda Lipid Profilinin ve Statin Tedavisinin Değerlendirilmesi: Üçüncü Basamak Bir Hastaneden Gerçek Hayat Verileri

Öz

Amaç: Dislipidemi, atriyal fibrilasyonun (AF) değiştirilebilir bir risk faktörüdür. Ancak hastaların büyük çoğunluğu ya düşük yoğunluklu lipoprotein kolesterol (LDL-C) düşürücü tedavi almıyor ya da LDL-C ve yüksek yoğunluklu olmayan lipoprotein kolesterol (non-HDL-C) hedeflerine ulaşamıyor. AF'li hastaların dislipidemi için tedavi edilip edilmediğini ve/veya tedavi edilirlerse hedef LDL-C ve non-HDL-C düzeylerinde olup olmadıklarını araştırmayı amaçladık. Gereç ve Yöntem: Bu kesitsel analiz 725 AF hastasını içermektedir ve 20 Mayıs 2023 ile 25 Kasım 2023 tarihleri arasında üçüncü basamak bir hastanenin kardiyoloji polikliniklerinde gerçekleştirildi. Hastaların demografik ve klinik özellikleri kaydedildi. Kardiyovasküler hastalık (CVD) risk tahmini için sistemik koroner risk tahmini-2 (SCORE2) ve yaşlı kişi versiyonu algoritmaları kullanıldı. Birincil koruma (PP) grubu, belirlenmiş aterosklerotik kardiyovasküler hastalığı (ASCVD) olmayan düşük-orta, yüksek ve çok yüksek CVD riski olan hastaları içermektedir ve ikincil önleme (SP) grubu, belirlenmiş ASCVD'si olan hastalardan oluşmaktadır. Bulgular: Katılımcıların yaş ortalaması 71,98± 9,01 olup hastaların %54,5'i (n=368) kadındı. Hastaların 207'si (%30,7) paroksismal AF, 468'i (%69,3) kalıcı AF idi. Dislipidemi ve hipertrigliseridemi prevalansı sırasıyla 364 (%53,9) ve 248 (%36,7) idi. Hastaların 9'u (%1,3) fibrat, 152'si (%22,5) ise statin tedavisi görüyordu. Ortalama LDL-C ve non-HDL-C sırasıyla 107,81±35,97 ve 135,42±41,19 olup, hedeflenen oranlara ulaşma oranları sırasıyla 62 (%9,2) ve 107 (%15,9) idi. Sonuç: Atriyal fibrilasyonu olan hastalarda dislipideminin kontrolü oldukça zayıftı ve en yaygın neden doktor ihmaliydi.

Anahtar Kelimeler

Evaluation of lipid profile and statin therapy in patients with atrial fibrillation: Real-life data from a tertiary hospital

Abstract

Aim: Dyslipidemia is a modifiable risk factor of atrial fibrillation (AF). However, the majority of patients either do not receive low-density lipoprotein cholesterol (LDL-C) lowering treatment or do not meet their LDL-C and non-high-density lipoprotein cholesterol (non-HDL-C) goal. We aimed to search whether patients with AF are being treated for dyslipidemia and/or are at target LDL-C and non-HDL-C levels if treated. Materials and Methods: This cross-sectional analysis includes 725 AF patients and was performed between 20 May 2023 and 25 November 2023, in cardiology outpatient clinics of a tertiary hospital. The demographic and clinical features of the patients were recorded. Systemic coronary risk estimation-2 (SCORE2) and old person version algorithms were used for cardiovascular disease (CVD) risk estimation. Primary prevention (PP) group involved patients with low-to-moderate, high and very high CVD risk without established atherosclerotic cardiovascular disease (ASCVD) and secondary prevention (SP) group was consisted of patients with established ASCVD. Results: The mean age of the participants was 71.98± 9.01 and 54.5% (n=368) of patients were females. 207 (30.7%) of patients were paroxysmal AF, and 468 (69.3%) were permanent AF. Prevalence of dyslipidemia and hypertriglyceridemia were 364 (53.9%) and 248 (36.7%) respectively. 9 (1.3%) and 152 (22.5%) of patients were on fibrate and statin treatment respectively. Mean LDL-C and non-HDL-C were 107.81±35.97 and 135.42±41.19 and their target attainment rates were 62 (9.2%) and 107 (15.9%), respectively. Conclusion: Control of dyslipidemia in patients with atrial fibrillation was severely poor and the most common cause was physician negligence.

Keywords

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Kardiyoloji

Bölüm

Araştırma Makalesi

Yazarlar

Abdulrahman Naser ^*
0000-0002-0954-6347
Türkiye

Yucel Uzun
0009-0002-0246-2404
Türkiye

Samet Sayılan
0000-0002-8959-8381
Türkiye

Oya Güven
0000-0002-6389-4561
Türkiye

Merve Demireller
0000-0002-5580-6015
Türkiye

Ahmet Ekmekci
0000-0001-5424-149X
Türkiye

Yayımlanma Tarihi

9 Aralık 2024

Gönderilme Tarihi

24 Ocak 2024

Kabul Tarihi

5 Eylül 2024

Yayımlandığı Sayı

Yıl 2024 Cilt: 63 Sayı: 4

DOI

https://doi.org/10.19161/etd.1418118

IZ

https://izlik.org/JA82DF34CA

Kaynak Göster

RIS / Bibtex

Vancouver

1.Abdulrahman Naser, Yucel Uzun, Samet Sayılan, Oya Güven, Merve Demireller, Ahmet Ekmekci. Evaluation of lipid profile and statin therapy in patients with atrial fibrillation: Real-life data from a tertiary hospital. ETD. 01 Aralık 2024;63(4):586-94. doi:10.19161/etd.1418118