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Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease

Cilt: 65 Sayı: 3 3 Eylül 2026
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Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease

Öz

Graves' disease (GD) may rarely present with hematologic findings and hepatic dysfunction. Diagnosis may be difficult, but early diagnosis is important to avoid delays in treatment. According to a recent literature review, the association of pancytopenia, autoimmune hemolytic anemia (AIHA) and hepatic dysfunction in GD has not been reported before. We report the case of a 57-year-old woman admitted to the intensive care unit with symptoms of heart failure and diagnosed as GD with pancytopenia, AIHA and impaired liver function tests. Corticosteroid and anti-thyroid treatment was initiated and clinical and laboratory findings improved within the first week. Pancytopenia, AIHA and hepatic dysfunction may occur as the first manifestation of the disease or may be seen in the course of Graves' disease. The occurrence of these severe findings is very rare and respond well to treatment.

Anahtar Kelimeler

Destekleyen Kurum

noe

Etik Beyan

none

Kaynakça

  1. 1. Burch, Henry B, and David S Cooper. Management of Graves Disease: A Review. JAMA vol. 314,23 (2015): 2544-54.
  2. 2. McLeod DS, Caturegli P, Cooper DS, Matos PG, Hutfless S. Variation in rates of autoimmune thyroid disease by race/ethnicity in US military personnel. JAMA. 2014;311(15):1563-1565.
  3. 3. Behera KK, Agrawal K, Adhya AK. Graves' Disease with Pancytopenia and Hepatic Dysfunction: A Rare Case Presentation. Indian J Nucl Med. 2019;34(1):38-41.
  4. 4. Lima, C. S., Zantut Wittmann, D. E., Castro, V., Tambascia, M. A., Lorand-Metze, I., Saad, et al. Pancytopenia in untreated patients with Graves' disease. Thyroid : official journal of the American Thyroid Association, 16(4), 403–409.
  5. 5. Pincet L, Gorostidi F. Graves Disease Causing Pancytopenia: Case Report and Literature Review. Clin Med Insights Case Rep. 2018;11:1179547618781090.
  6. 6. Kandinata SG, Soelistijo SA, Amrita PNA. Graves' Disease Presenting as Autoimmune Hemolytic Anemia. Am J Case Rep. 2021;22:e930705.
  7. 7. Hegazi MO, Ahmed S. Atypical clinical manifestations of graves' disease: an analysis in depth. J Thyroid Res. 2012;2012:768019.
  8. 8. Meftah N, Sedaghat S, Rabizadeh S, Seifouri S, Nasirimeh K, Nakhjavani M. Graves' disease with pancytopenia:

Ayrıntılar

Birincil Dil

İngilizce

Konular

Hematoloji, Endokrinoloji, Gastroenteroloji ve Hepatoloji

Bölüm

Olgu Sunumu

Yazarlar

Yayımlanma Tarihi

3 Eylül 2026

Gönderilme Tarihi

29 Mayıs 2024

Kabul Tarihi

18 Haziran 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 65 Sayı: 3

DOI

https://doi.org/10.19161/etd.1491772

IZ

https://izlik.org/JA72DU99ZF

Kaynak Göster

RIS / Bibtex
APA
Midik, M. M., Kılınçer Bozgül, Ş. M., Sarer Yürekli, B., & Bozkurt, D. (2026). Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease. Ege Tıp Dergisi, 65(3), 620-623. https://doi.org/10.19161/etd.1491772
AMA
1.Midik MM, Kılınçer Bozgül ŞM, Sarer Yürekli B, Bozkurt D. Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease. ETD. 2026;65(3):620-623. doi:10.19161/etd.1491772
Chicago
Midik, Mustafa Murat, Şükriye Miray Kılınçer Bozgül, Banu Sarer Yürekli, ve Devrim Bozkurt. 2026. “Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease”. Ege Tıp Dergisi 65 (3): 620-23. https://doi.org/10.19161/etd.1491772.
EndNote
Midik MM, Kılınçer Bozgül ŞM, Sarer Yürekli B, Bozkurt D (01 Eylül 2026) Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease. Ege Tıp Dergisi 65 3 620–623.
IEEE
[1]M. M. Midik, Ş. M. Kılınçer Bozgül, B. Sarer Yürekli, ve D. Bozkurt, “Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease”, ETD, c. 65, sy 3, ss. 620–623, Eyl. 2026, doi: 10.19161/etd.1491772.
ISNAD
Midik, Mustafa Murat - Kılınçer Bozgül, Şükriye Miray - Sarer Yürekli, Banu - Bozkurt, Devrim. “Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease”. Ege Tıp Dergisi 65/3 (01 Eylül 2026): 620-623. https://doi.org/10.19161/etd.1491772.
JAMA
1.Midik MM, Kılınçer Bozgül ŞM, Sarer Yürekli B, Bozkurt D. Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease. ETD. 2026;65:620–623.
MLA
Midik, Mustafa Murat, vd. “Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease”. Ege Tıp Dergisi, c. 65, sy 3, Eylül 2026, ss. 620-3, doi:10.19161/etd.1491772.
Vancouver
1.Mustafa Murat Midik, Şükriye Miray Kılınçer Bozgül, Banu Sarer Yürekli, Devrim Bozkurt. Co-existence of pancytopenia, autoimmune hemolytic anemia and hepatic dysfunction in intensive care unit patient: Graves’ disease. ETD. 01 Eylül 2026;65(3):620-3. doi:10.19161/etd.1491772

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