Araştırma Makalesi

Evaluation of the effect of cervical cord lesion on upper extremity function in newly diagnosed persons with multiple sclerosis running head: upper extremity function in multiple sclerosis

Cilt: 64 Sayı: 3 8 Eylül 2025
Ege Tıp Dergisi Kapak
Ege Tıp Dergisi
PDF İndir
TR EN

Evaluation of the effect of cervical cord lesion on upper extremity function in newly diagnosed persons with multiple sclerosis running head: upper extremity function in multiple sclerosis

Abstract

Aim: To evaluate the effect of cervical cord lesions on upper extremity functions in persons with very early-stage multiple sclerosis (MS) and describe the factors that affect the upper extremity functions in that population. Materials and Methods: Two hundred forty-five persons with MS (pwMS) were diagnosed 24 months after the first symptoms and three hundred seventy-eight pwMS initiated disease-modified treatment (DMT) within six months after diagnosis were included to study. Nine-Hole Peg Test (N-HPT) were performed to evaluate upper extremity functions. Participants divided two groups according to presence of cervical cord lesion. Results: There were no significant differences between groups in terms of age, gender, disease duration, and the number of relapses. However, the total Expanded Disability Status Score (EDSS) score, pyramidal and sensory functional system scores were higher in pwMS with cervical cord lesions than without cervical cord lesions. Average and dominant hand N-HPT performance times were found significantly longer in pwMS with cervical cord lesion than without cervical cord lesion in participants-initiated DMT within six months after diagnosis. However, there were no significant differences between groups in participants diagnosed 24 months after first symptoms Age, disease duration, and time from diagnosis to treatment were identified as significant factors influencing N-HPT performance. PwMS who were younger, had a shorter disease duration, and received treatment sooner after diagnosis showed better performance than others. Conclusion: Our study highlights the influence of cervical cord lesions on upper extremity function, even in the early stages of MS, and underscores the importance of early diagnosis and prompt initiation of DMTs.

Keywords

Kaynakça

  1. Johansson S, Ytterberg C, Claesson IM, Lindberg J, Hillert J, Andersson M, et al. High concurrent presence of disability in multiple sclerosis. J Neurol. 2007 Jun 2;254(6):767–73.
  2. Bertoni R, Lamers I, Chen CC, Feys P, Cattaneo D. Unilateral and bilateral upper limb dysfunction at body functions, activity and participation levels in people with multiple sclerosis. Multiple Sclerosis Journal. 2015 Oct 6;21(12):1566–74.
  3. Park S, Park JY. Grip strength in post-stroke hemiplegia. J Phys Ther Sci. 2016;28(2):677–9.
  4. Bohannon RW.

    Grip Strength: An Indispensable Biomarker For Older Adults

    . Clin Interv Aging. 2019 Oct;Volume 14:1681–91.
  5. Feys P, Lamers I, Francis G, Benedict R, Phillips G, LaRocca N, et al. The Nine-Hole Peg Test as a manual dexterity performance measure for multiple sclerosis. Multiple Sclerosis Journal. 2017 Apr 16;23(5):711–20.
  6. Ovacik U, Tarakci E, Ozdemir Z. Upper limb dysfunction in people with early-stage Multiple Sclerosis: Perceived performance can be misleading. Mult Scler Relat Disord. 2023 Nov 1;79.
  7. Weier K, Mazraeh J, Naegelin Y, Thoeni A, Hirsch JG, Fabbro T, et al. Biplanar MRI for the assessment of the spinal cord in multiple sclerosis. Multiple Sclerosis Journal. 2012 Nov 26;18(11):1560–9.
  8. Lukas C, Sombekke MH, Bellenberg B, Hahn HK, Popescu V, Bendfeldt K, et al. Relevance of Spinal Cord Abnormalities to Clinical Disability in Multiple Sclerosis: MR Imaging Findings in a Large Cohort of Patients. Radiology. 2013 Nov;269(2):542–52.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Nöroloji ve Nöromüsküler Hastalıklar

Bölüm

Araştırma Makalesi

Yazarlar

Yayımlanma Tarihi

8 Eylül 2025

Gönderilme Tarihi

24 Aralık 2024

Kabul Tarihi

6 Mayıs 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 64 Sayı: 3

DOI

https://doi.org/10.19161/etd.1604450

IZ

https://izlik.org/JA43GX55KP

Kaynak Göster

RIS / Bibtex
Vancouver
1.Asiye Tuba Özdoğar, Ergi Kaya, Bilge Piri Cinar, Nurbanu Aygündüz, Seda Daştan, Hilal Karakaş, Cavid Baba, Serkan Ozakbas. Evaluation of the effect of cervical cord lesion on upper extremity function in newly diagnosed persons with multiple sclerosis running head: upper extremity function in multiple sclerosis. ETD. 01 Eylül 2025;64(3):468-74. doi:10.19161/etd.1604450

Ege Tıp Dergisi, makalelerin Atıf-Gayri Ticari-Aynı Lisansla Paylaş 4.0 Uluslararası (CC BY-NC-SA 4.0) lisansına uygun bir şekilde paylaşılmasına izin verir.