Araştırma Makalesi

The relationship between endothelial activation and stress index with survival and early mortality in acute myeloid leukemia

Cilt: 64 Sayı: 4 8 Aralık 2025
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The relationship between endothelial activation and stress index with survival and early mortality in acute myeloid leukemia

Abstract

Aim: The Endothelial Activation and Stress Index (EASIX) score is used as a marker of endothelial damage and used to predict acute graft-versus-host disease and sinusoidal obstruction syndrome. We wanted to evaluate the effects of EASIX, modified EASIX (mEASIX) and sepsis modified EASIX (sEASIX) on early mortality and overall survival (OS) in patients with acute myeloid leukemia. Materials and Methods: We reviewed patients diagnosed and followed up with Acute Myeloid Leukemia (AML) in our Hematology Department, retrospectively. Patients between 18 -70 years of age and who were administered 7+3 (7 days cytarabine, and 3 days anthracycline) chemotherapy protocol (except acute promyelocytic leukemia) were included. EASIX, mEASIX and sEASIX scores of the patients, both at the time of diagnosis and at the end of the 4th week, were calculated. Results: Seventy-five patients were included in the study. The mean age was 49.05 (19-68) years and 41% were alive. EASIX and mEASIX scores measured both at the time of diagnosis and at the end of induction therapy were found to be significantly associated with early mortality (p=0.01, p<0.01) and OS (p<0.01, p<0.01). Conclusion: There is no specific scoring system or marker that we can use practically in the clinic to show early mortality in these patients who receive intensive treatment in AML. Of course, there are many factors that can affect mortality in this period. However, based on the current results, we think that EASIX, mEASIX and sEASIX scores can be used with other prognostic factors to predict early mortality and survival.

Keywords

Etik Beyan

The study was conducted in accordance with the Declaration of Helsinki, Ethical Principles for Medical Research. This study was approved by Trakya University Faculty of Medicine Ethical Committee (TUTF-BAEK2020/439).

Kaynakça

  1. Shallis RM, Wang R, Davidoff A and et al. Epidemiology of acute myeloid leukemia: Recent progress and enduring challenges. Blood Rev. 2019 Jul;36:70-87.
  2. Song GY, Jung SH, Kim K, et al. Endothelial activation and stress index (EASIX) is a reliable predictor for overall survival in patients with multiple myeloma. BMC Cancer. 2020 Aug 24;20(1):803.
  3. Merz A, Germing U, Kobbe G, et al. EASIX for prediction of survival in lower-risk myelodysplastic syndromes. Blood Cancer J. 2019 Nov 11;9(11):85.
  4. Pennisi M, Sanchez-Escamilla M, Flynn JR, et al. Modified EASIX predicts severe cytokine release syndrome and neurotoxicity after chimeric antigen receptor T cells. Blood Adv. 2021 Sep 14;5(17):3397-3406.
  5. Li Y, Jiang L, Song T, et al. A call for better understanding the role of albumin in mediating VE-cadherin phosphorylation and endothelial barrier dysfunction in septic patients. Crit Care. 2021 Jul 1;25(1):232.
  6. Sanchez-Escamilla M, Flynn J, Devlin S, et al. EASIX score predicts inferior survival after allogeneic hematopoietic cell transplantation. Bone Marrow Transplant. 2023 May;58(5):498-505.
  7. Vythoulkas D, Tsirigotis P, Griniezaki M, et aI. Endothelial Dysfunction Syndromes after Allogeneic Stem Cell Transplantation. Cancers (Basel). 2023 Jan 22;15(3):680.
  8. Aldecoa C, Llau JV, Nuvials X and Artigas A. Role of albumin in the preservation of endothelial glycocalyx integrity and the microcirculation: a review. Ann Intensive Care. 2020 Jun 22;10(1):85.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Hematoloji

Bölüm

Araştırma Makalesi

Yazarlar

Yayımlanma Tarihi

8 Aralık 2025

Gönderilme Tarihi

2 Şubat 2025

Kabul Tarihi

3 Temmuz 2025

Yayımlandığı Sayı

Yıl 2025 Cilt: 64 Sayı: 4

DOI

https://doi.org/10.19161/etd.1620976

IZ

https://izlik.org/JA98UE36WC

Kaynak Göster

RIS / Bibtex
Vancouver
1.Ufuk Demirci, Elif Umit, Erge Aslan, Tuğcan Alp Kırkızlar, Hakkı Onur Kırkızlar, Ahmet Muzaffer Demir. The relationship between endothelial activation and stress index with survival and early mortality in acute myeloid leukemia. ETD. 01 Aralık 2025;64(4):606-11. doi:10.19161/etd.1620976

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