Araştırma Makalesi

Predictors and clinical characteristics of ruptured ectopic pregnancy: A retrospective analysis

Cilt: 65 Sayı: 1 9 Mart 2026
Ege Tıp Dergisi Kapak
Ege Tıp Dergisi
PDF İndir
TR EN

Predictors and clinical characteristics of ruptured ectopic pregnancy: A retrospective analysis

Abstract

Aim: This study aimed to identify and analyze the specific risk factors and clinical characteristics associated with tubal rupture in women with ectopic pregnancy (EP). Materials and Methods: A retrospective analysis was conducted on 180 women diagnosed with EP at a tertiary care center between 2015 and 2024. Patients were stratified into two groups: those with tubal rupture (n=132) and those with unruptured EP (n=48). Patient demographics, reproductive history, presenting clinical signs, serum beta-human chorionic gonadotropin (β-hCG) levels, and operative outcomes were collected. Results: Women with ruptured EP were significantly younger (31.2 ± 5.5 vs. 33.3 ± 5.8 years; p = 0.026) and presented with significantly lower mean serum β-hCG concentrations (3037.9 ± 4438.5 vs. 5483.6 ± 5300.8 mIU/mL; p = 0.006). A history of a prior EP and tubal surgery was more frequent among unruptured cases (p = 0.018 and p = 0.017, respectively). In multivariable logistic regression, younger age (adjusted odds ratio [aOR] 0.91; 95% CI, 0.84–0.98; p = 0.018), the presence of abdominal pain (aOR 3.27; 95% CI, 1.06–10.05; p = 0.039), and lower serum β-hCG (p <0.001) were confirmed as independent predictors of rupture. Salpingectomy was the predominant surgical procedure in ruptured cases (97.7%) compared to unruptured cases (89.6%; p = 0.006). Conclusion: Tubal rupture in EP was independently associated with younger age, lower serum β-hCG levels, and the presence of abdominal pain. A history of EP was observed more frequently among unruptured cases

Keywords

Destekleyen Kurum

Yoktur.

Etik Beyan

Bu çalışma Helsinki Bildirgesi prensiplerine uygun olarak gerçekleştirildi. Çalışmaya Sağlık Bilimleri Üniversitesi, Kartal Koşuyolu Eğitim ve Araştırma Hastanesi Klinik Araştırmalar Etik Kurulu'nun 2024/14/891 sayılı onayı alındı.

Teşekkür

Yoktur.

Kaynakça

  1. Mullany K, Minneci M, Monjazeb R, C Coiado O. Overview of ectopic pregnancy diagnosis, management, and innovation. Womens Health (Lond). 2023;19:17455057231160349.
  2. Papageorgiou D, Sapantzoglou I, Prokopakis I, Zachariou E. Tubal Ectopic Pregnancy: From Diagnosis to Treatment. Biomedicines. 2025;13(6):1465.
  3. Faraji Darkhaneh R, Asgharnia M, Farahmand Porkar N, Alipoor AA. Predictive value of maternal serum β-hCG concentration in the ruptured tubal ectopic pregnancy. Iran J Reprod Med. 2015;13(2):101-106.
  4. Skinner A, Jones P. Negative betahCG: positive ectopic pregnancy. N Z Med J. 2003;116(1183):U630.
  5. Galstyan K, Kurzel RB. Serum beta-hCG titers do not predict ruptured ectopic pregnancy. Int J Fertil Womens Med. 2006;51(1):14-16.
  6. Gizaw NT, K/Mariam MA, Fayera MG. Magnitude of ectopic pregnancy, management methods, and its associated factors among pregnant women attending Ambo University Referral Hospital in Oromia Regional State, Ethiopia: A seven years retrospective institutional based cross-sectional study. PLOS Glob Public Health. 2025;5(6):e0004611.
  7. Roussos D, Panidis D, Matalliotakis I, et al. Factors that may predispose to rupture of tubal ectopic pregnancy. Eur J Obstet Gynecol Reprod Biol. 2000;89(1):15-17.
  8. National Guideline Alliance (UK). Diagnostic accuracy of ultrasound features for tubal ectopic pregnancy: Ectopic pregnancy and miscarriage: diagnosis and initial management: Evidence review A. London: National Institute for Health and Care Excellence (NICE); 2019 Apr. (NICE Guideline, No. 126.) Available from: https://www.ncbi.nlm.nih.gov/books/NBK576537/

Ayrıntılar

Birincil Dil

İngilizce

Konular

Kadın Hastalıkları ve Doğum

Bölüm

Araştırma Makalesi

Yazarlar

Yayımlanma Tarihi

9 Mart 2026

Gönderilme Tarihi

18 Eylül 2025

Kabul Tarihi

28 Ekim 2025

Yayımlandığı Sayı

Yıl 2026 Cilt: 65 Sayı: 1

DOI

https://doi.org/10.19161/etd.1786283

IZ

https://izlik.org/JA69MK93WZ

Kaynak Göster

RIS / Bibtex
Vancouver
1.Yeliz Çeçen Dönmez, Esra Keles, Fatih Şanlıkan, Sahra Sultan Kara, İsmail Bağlar, Cansu Ergenç, Sümeyye Nur Gökgöz, Şevki Göksun Gökulu. Predictors and clinical characteristics of ruptured ectopic pregnancy: A retrospective analysis. ETD. 01 Mart 2026;65(1):75-81. doi:10.19161/etd.1786283

Ege Tıp Dergisi, makalelerin Atıf-Gayri Ticari-Aynı Lisansla Paylaş 4.0 Uluslararası (CC BY-NC-SA 4.0) lisansına uygun bir şekilde paylaşılmasına izin verir.