Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life

Aslı Geçgel; Zeynep Gökdere; Oğuzcan Özkan; Gürdeniz Serin; Melis Palamar; Şaziye Burçak Karaca; Erdem Göker; Ulus Ali Şanlı

doi:10.19161/etd.1802914

TR EN

Erişkin granüloza hücreli tümörlerde kuru göz hastalığının risk faktörleri: Yaşam kalitesi açısından bulgular

Öz

Amaç: Erişkin granüloza hücreli tümörler (EGHT), genellikle uzun klinik seyir ve geç nükslerle karakterize, nadir görülen östrojen üreten over neoplazmlarıdır. Bu hasta grubunda kuru göz hastalığının (KGH) araştırılması önemlidir; çünkü EGHT’ye bağlı hormonal değişiklikler ve uygulanan tedaviler oküler sağlığı etkileyebilir. Bu çalışmanın amacı, EGHT hastalarında KGH sıklığını belirlemek ve KGH ile yaş, menopoz durumu, klinikopatolojik özellikler, komorbiditeler ve onkolojik tedaviler arasındaki ilişkileri değerlendirmektir. Gereç ve Yöntem: Bu retrospektif, tek merkezli çalışmada, 2012–2024 yılları arasında tanı almış, histopatolojik olarak doğrulanmış 55 EGHT hastası değerlendirildi. KGH; oftalmoloji konsültasyon kayıtları, belgelenmiş oküler semptomlar ve Schirmer testi sonuçları (≤5 mm/5 dk) dâhil olmak üzere objektif değerlendirmeler temel alınarak tanımlandı. Klinikopatolojik parametreler, menopoz durumu, adjuvan tedaviler, komorbiditeler ve KGH arasındaki ilişkiler, IBM SPSS Statistics for Windows, Sürüm 22.0 (IBM Corp., Armonk, NY, ABD) kullanılarak gerçekleştirilen tek değişkenli ve çok değişkenli lojistik regresyon analizleri ile değerlendirildi. Bulgular: KGH, hastaların %23,6’sında (n=13) saptandı. KGH olan hastalar, düzeltilmemiş karşılaştırmalarda tanı anında daha yaşlıydı (ortalama 55,2’ye karşı 48,6 yıl); ancak lojistik regresyon analizlerinde yaşın KGH ile bağımsız bir ilişkisi gösterilemedi. Tek değişkenli analizlerde KGH ile menopoz durumu, ER veya inhibin ekspresyonu, FIGO evresi, endometrial patoloji, nüks veya adjuvan tedavi türü arasında istatistiksel olarak anlamlı bir ilişki gözlenmedi. Çok değişkenli lojistik regresyon modelinde komorbidite (OR 1,696; %95 GA 0,809–3,554; p=0,162) ve tümör çapı >10 cm (OR 2,375; %95 GA 0,648–8,708; p=0,192) KGH olasılığında artış yönünde, ancak istatistiksel olarak anlamlı olmayan eğilimler gösterdi. Tanımlayıcı karşılaştırmalarda paklitaksel bazlı tedavi alan EGHT hastalarında KGH prevalansı sayısal olarak daha yüksekti, ancak bu fark istatistiksel olarak anlamlı değildi. Sonuç: KGH, EGHT tanılı hastalarda özellikle ileri yaştaki bireylerde, komorbiditesi olanlarda ve taksan temelli tedavi alan hastalarda göz önünde bulundurulmalıdır. Standart onkolojik takip sürecine kısa bir oküler yüzey taramasının entegre edilmesi, gözden kaçabilen semptomların saptanmasını kolaylaştırabilir ve hasta konforu ile yaşam kalitesini artırabilir.

Anahtar Kelimeler

Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life

Öz

Aim: Adult granulosa cell tumors (AGCTs) are rare estrogen-producing ovarian neoplasms that typically exhibit a prolonged clinical course and late recurrences. Investigating dry eye disease (DED) in this patient population is essential, as AGCT-related hormonal alterations and therapeutic interventions may affect ocular health. This study aimed to determine the prevalence of DED among patients with AGCT and to assess its associations with age, menopausal status, clinicopathological features, comorbidities, and oncologic treatments. Materials and Methods: This retrospective, single-center study evaluated 55 patients with histopathologically confirmed AGCT diagnosed between 2012 and 2024. DED was identified based on ophthalmology consultation records, documented ocular symptoms, and objective testing, including Schirmer test results (≤5 mm/5 min). Associations among clinicopathological parameters, menopausal status, adjuvant treatments, comorbidities, and DED were assessed using univariate and multivariate logistic regression analyses, conducted with SPSS Statistics for Windows, Version 22.0 (IBM Corp., Armonk, NY, USA). Results: DED was detected in 23.6% (n=13) of patients. Patients with DED were older at diagnosis in unadjusted comparisons (mean 55.2 vs. 48.6 years); however, age was not independently associated with DED in logistic regression analyses. In univariate analyses, no statistically significant associations were observed between DED and menopausal status, ER or inhibin expression, FIGO stage, endometrial pathology, recurrence, or type of adjuvant therapy. In the multivariable logistic regression model, comorbidity (OR 1.696; 95% CI, 0.809–3.554; p=0.162) and tumor size >10 cm (OR 2.375; 95% CI, 0.648–8.708; p=0.192) showed non-significant trends toward higher odds of DED. In descriptive comparisons, patients who received paclitaxel-based therapy had a numerically higher prevalence of DED, although this difference was not statistically significant. Conclusions: Dry eye disease should be actively considered in patients with adult granulosa cell tumors, especially among older adults, individuals with comorbidities, and those receiving taxane-based therapy. Integrating brief ocular surface screening into standard oncologic follow-up could facilitate the identification of underrecognized symptoms and enhance patient comfort and quality of life.

Anahtar Kelimeler

Destekleyen Kurum

Ege Üniversitesi Tıp Fakültesi

Etik Beyan

Çalışma Helsinki Bildirgesi ilkelerine uygun olarak yürütülmüş olup, Ege Üniversitesi Tıbbi Araştırmalar Etik Kurulu tarafından 04.09.2025 tarihli ve 25-9T/79 karar numarasıyla onaylanmıştır.

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Onkoloji

Bölüm

Araştırma Makalesi

Yazarlar

Aslı Geçgel ^*
0000-0001-6942-9858
Türkiye

Zeynep Gökdere
0000-0002-8868-988X
Türkiye

Oğuzcan Özkan
0000-0002-4075-7775
Türkiye

Gürdeniz Serin
0000-0003-4204-0601
Türkiye

Melis Palamar
0000-0002-2494-0131
Türkiye

Şaziye Burçak Karaca
0000-0003-2638-1625
Türkiye

Erdem Göker
0000-0001-6180-713X
Türkiye

Ulus Ali Şanlı
0000-0002-0062-6105
Türkiye

Yayımlanma Tarihi

10 Haziran 2026

Gönderilme Tarihi

15 Ekim 2025

Kabul Tarihi

9 Ocak 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 65 Sayı: 2

DOI

https://doi.org/10.19161/etd.1802914

IZ

https://izlik.org/JA79UL97AT

Kaynak Göster

RIS / Bibtex

APA

Geçgel, A., Gökdere, Z., Özkan, O., Serin, G., Palamar, M., Karaca, Ş. B., Göker, E., & Şanlı, U. A. (2026). Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life. Ege Tıp Dergisi, 65(2), 237-246. https://doi.org/10.19161/etd.1802914

AMA

1.Geçgel A, Gökdere Z, Özkan O, vd. Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life. ETD. 2026;65(2):237-246. doi:10.19161/etd.1802914

Chicago

Geçgel, Aslı, Zeynep Gökdere, Oğuzcan Özkan, vd. 2026. “Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life”. Ege Tıp Dergisi 65 (2): 237-46. https://doi.org/10.19161/etd.1802914.

EndNote

Geçgel A, Gökdere Z, Özkan O, Serin G, Palamar M, Karaca ŞB, Göker E, Şanlı UA (01 Haziran 2026) Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life. Ege Tıp Dergisi 65 2 237–246.

IEEE

[1]A. Geçgel vd., “Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life”, ETD, c. 65, sy 2, ss. 237–246, Haz. 2026, doi: 10.19161/etd.1802914.

ISNAD

Geçgel, Aslı - Gökdere, Zeynep - Özkan, Oğuzcan - Serin, Gürdeniz - Palamar, Melis - Karaca, Şaziye Burçak - Göker, Erdem - Şanlı, Ulus Ali. “Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life”. Ege Tıp Dergisi 65/2 (01 Haziran 2026): 237-246. https://doi.org/10.19161/etd.1802914.

JAMA

1.Geçgel A, Gökdere Z, Özkan O, Serin G, Palamar M, Karaca ŞB, Göker E, Şanlı UA. Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life. ETD. 2026;65:237–246.

MLA

Geçgel, Aslı, vd. “Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life”. Ege Tıp Dergisi, c. 65, sy 2, Haziran 2026, ss. 237-46, doi:10.19161/etd.1802914.

Vancouver

1.Aslı Geçgel, Zeynep Gökdere, Oğuzcan Özkan, Gürdeniz Serin, Melis Palamar, Şaziye Burçak Karaca, Erdem Göker, Ulus Ali Şanlı. Risk factors for dry eye disease in adult granulosa cell tumors: Implications for quality of life. ETD. 01 Haziran 2026;65(2):237-46. doi:10.19161/etd.1802914