Araştırma Makalesi

Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers

Cilt: 65 Sayı: 2 10 Haziran 2026
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Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers

Öz

Aim: Preeclampsia (PE) poses a significant threat to maternal and fetal health. The Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) index has emerged as a novel biomarker providing information on inflammation and nutritional status. The aim of this study is to evaluate the performance of the HALP index in diagnosing PE, comparing it with other commonly used inflammatory and nutritional markers. Materials and Methods: In this retrospective case-control study, 173 women who gave birth at a tertiary hospital between 2020 and 2025 and were diagnosed with PE were examined, along with a control group of 185 healthy pregnant women. The HALP score, Prognostic Nutritional Index (PNI), Neutrophil-Lymphocyte Ratio (NLR), Systemic Immune-Inflammation Index (SII), and serum uric acid/creatinine ratio (sUA/sCr) were calculated for the participants. Diagnostic performance was evaluated using ROC curves and comparing AUC (Area Under the Curve) values. Results: In women in the PE group, the HALP score (2.5 vs. 3.8) and PNI value (34.5 vs. 41.0) were significantly lower (p < 0.001 for both). In contrast, NLR, SII, serum uric acid level, and sUA/sCr ratio were significantly higher in the PE group (all p < 0.001). According to ROC analysis, uric acid had the highest diagnostic accuracy with an AUC value of 0.805 (95% CI: 0.758-0.852). The HALP score showed a significant but relatively low diagnostic accuracy (AUC: 0.625, 95% CI: 0.566-0.684),(p < 0.01 for all). Conclusions: Although the HALP score is significantly lower in women with preeclampsia, its diagnostic performance during diagnosis lags behind established biomarkers such as uric acid, sUA/sCr, PNI, and SII.

Anahtar Kelimeler

Destekleyen Kurum

yok

Etik Beyan

İnsan katılımcıların yer aldığı çalışmalarda gerçekleştirilen tüm işlemler, kurumun ve/veya ulusal araştırma komitesinin etik standartlarına ve 1964 Helsinki Bildirgesi ile onun sonraki değişikliklerine veya karşılaştırılabilir etik ilkelere uygun olarak yürütülmüştür. Çalışma, 30.10.2025 tarihinde Sağlık Bilimleri Üniversitesi Türkiye, Kartal Şehir Hastanesi Etik Kurulu tarafından [Karar No: 2025/010.99/21/30] ile onaylanmıştır.”

Teşekkür

yok

Kaynakça

  1. Seyhanli Z, Bayraktar B, Karabay G, Filiz AA, Bucak M, Agaoglu RT, et al. Can maternal inflammatory and nutritional status, evaluated by the hemoglobin, albumin, lymphocyte, and platelet (HALP) score and the prognostic nutritional index (PNI) in the first trimester, predict late-onset fetal growth restriction? BMC Pregnancy Childbirth. 2024;24(1):620.
  2. Dai H, Shi Q. The HALP score may require modification for non-cancer prognosis. Int Urol Nephrol. 2024;56(5):1343.
  3. Hrubaru I, Motoc A, Dumitru C, Bratosin F, Fericean RM, Alambaram S, et al. Assessing the utility of hemoglobin, HALP score, FAR ratio, and coagulation parameters as predictors for preterm birth. Children (Basel). 2023;10(3):527.
  4. Han Q, Zheng S, Chen X, Gao Y, Zhang H, Lin N. The prognostic nutritional index is associated with preeclampsia in twin pregnancies. BMC Pregnancy Childbirth. 2025;25(1):568. doi:10.1186/s12884-025-07669-y.
  5. Dal Y, Karaca SG, Akkuş F, Karagün Ş, Nessar AZ, Coşkun A. Evaluation of the diagnostic value of the HALP score, uric acid value, and uric acid-creatinine ratio in preeclampsia. Ceska Gynekol. 2024;89(3):180-7.
  6. ACOG Practice Bulletin No. 222: Gestational hypertension and preeclampsia. Obstet Gynecol. 2020;135(6):e237-50. doi:10.1097/AOG.0000000000003891.
  7. Gogoi P, Sinha P, Gupta B, et al. Neutrophil-to-lymphocyte ratio and platelet indices in preeclampsia. Int J Gynaecol Obstet. 2019;144(1):16-20. doi:10.1002/ijgo.12701.
  8. Qian C, Liu J, Meng C, Cheng J, Wu B, Liao J. The significant prognostic value of the hemoglobin, albumin, lymphocyte, and platelet (HALP) score in digestive system cancers: a systematic review and meta-analysis. BMC Cancer. 2025;25(1):1577. doi:10.1186/s12885-025-15068-x.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Cerrahi (Diğer)

Bölüm

Araştırma Makalesi

Yazarlar

Yayımlanma Tarihi

10 Haziran 2026

Gönderilme Tarihi

20 Kasım 2025

Kabul Tarihi

5 Şubat 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 65 Sayı: 2

DOI

https://doi.org/10.19161/etd.1827265

IZ

https://izlik.org/JA58JJ67PH

Kaynak Göster

RIS / Bibtex
APA
Bağlar, İ., Şanlıkan, F., Keles, E., Yiğit Çivi, B., Gökulu, Ş. G., Aşci, H., Ağır, D., & Sezgin, B. (2026). Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers. Ege Tıp Dergisi, 65(2), 268-274. https://doi.org/10.19161/etd.1827265
AMA
1.Bağlar İ, Şanlıkan F, Keles E, vd. Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers. ETD. 2026;65(2):268-274. doi:10.19161/etd.1827265
Chicago
Bağlar, İsmail, Fatih Şanlıkan, Esra Keles, vd. 2026. “Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers”. Ege Tıp Dergisi 65 (2): 268-74. https://doi.org/10.19161/etd.1827265.
EndNote
Bağlar İ, Şanlıkan F, Keles E, Yiğit Çivi B, Gökulu ŞG, Aşci H, Ağır D, Sezgin B (01 Haziran 2026) Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers. Ege Tıp Dergisi 65 2 268–274.
IEEE
[1]İ. Bağlar vd., “Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers”, ETD, c. 65, sy 2, ss. 268–274, Haz. 2026, doi: 10.19161/etd.1827265.
ISNAD
Bağlar, İsmail - Şanlıkan, Fatih - Keles, Esra - Yiğit Çivi, Buket - Gökulu, Şevki Göksun - Aşci, Hilal - Ağır, Dilanur - Sezgin, Burak. “Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers”. Ege Tıp Dergisi 65/2 (01 Haziran 2026): 268-274. https://doi.org/10.19161/etd.1827265.
JAMA
1.Bağlar İ, Şanlıkan F, Keles E, Yiğit Çivi B, Gökulu ŞG, Aşci H, Ağır D, Sezgin B. Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers. ETD. 2026;65:268–274.
MLA
Bağlar, İsmail, vd. “Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers”. Ege Tıp Dergisi, c. 65, sy 2, Haziran 2026, ss. 268-74, doi:10.19161/etd.1827265.
Vancouver
1.İsmail Bağlar, Fatih Şanlıkan, Esra Keles, Buket Yiğit Çivi, Şevki Göksun Gökulu, Hilal Aşci, Dilanur Ağır, Burak Sezgin. Is HALP a new marker for preeclampsia? Retrospective evaluation of the diagnostic accuracy of the HALP index compared to other inflammatory and nutritional markers. ETD. 01 Haziran 2026;65(2):268-74. doi:10.19161/etd.1827265

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