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Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case

Cilt: 65 Sayı: 3 3 Eylül 2026
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Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case

Öz

The aim of this study is to present a case involving the extremely rare coexistence of chronic myeloid leukemia (CML) and chronic lymphocytic leukemia (CLL), and to contribute to the identification of accurate diagnostic approaches and appropriate therapeutic strategies. A 55-year-old woman referred to our outpatient clinic for leukocytosis was found to have both marked neutrophilia and lymphocytosis on initial laboratory evaluation. Peripheral blood smear demonstrated mature lymphocytes along with an increased granulocytic series and myeloid precursor cells; no blasts were observed. After exclusion of infectious etiologies, flow cytometric analysis revealed CD19, CD23, and CD5 positivity, consistent with CLL. Concurrent fluorescence in situ hybridization (FISH) analysis demonstrated the presence of the BCR:ABL1 fusion. Subsequent bone marrow biopsy confirmed the concurrent presence of CML and CLL. The patient was started on imatinib therapy and remains under close hematologic follow-up.

Anahtar Kelimeler

Kaynakça

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  3. 3. Bhagavathi S, Borromeo V, Desai H, Crisan D. Case report and literature review: a rare patient with chronic myeloid leukemia and chronic lymphocytic leukemia. Ann Clin Lab Sci. 2008;38:405-409.
  4. 4. Rahman K, George S, Mangal S, Mehta A. Simultaneous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: report of an unusual case. Indian J Pathol Microbiol. 2013;56:453-456.
  5. 5. Boddu P, Gibbons J, Burger JA, Sivina M, Thakral B, Kanagal-Shamanna R, Ferrajoli A. Co-occurrence of chronic myeloid leukemia with chronic lymphocytic leukemia: a report of two cases. Leuk Lymphoma. 2019;60:1568-1571.
  6. 6. Abdalla E, Fadul A, Osman AE, Mohamed G, Soliman DS, Shawayli H, et al. Review of rare association between chronic lymphocytic leukemia and chronic myeloid leukemia. Blood. 2024;144(Suppl 1):6805.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Klinik Tıp Bilimleri (Diğer)

Bölüm

Olgu Sunumu

Yazarlar

Yayımlanma Tarihi

3 Eylül 2026

Gönderilme Tarihi

4 Aralık 2025

Kabul Tarihi

4 Mayıs 2026

Yayımlandığı Sayı

Yıl 2026 Cilt: 65 Sayı: 3

DOI

https://doi.org/10.19161/etd.1836093

IZ

https://izlik.org/JA86ZM33LK

Kaynak Göster

RIS / Bibtex
APA
Taghıyeva, F., Köseoğlu, F. D., & Tuncer, S. S. (2026). Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case. Ege Tıp Dergisi, 65(3), 608-611. https://doi.org/10.19161/etd.1836093
AMA
1.Taghıyeva F, Köseoğlu FD, Tuncer SS. Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case. ETD. 2026;65(3):608-611. doi:10.19161/etd.1836093
Chicago
Taghıyeva, Fatma, Fatoş Dilan Köseoğlu, ve Saniye Sevim Tuncer. 2026. “Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case”. Ege Tıp Dergisi 65 (3): 608-11. https://doi.org/10.19161/etd.1836093.
EndNote
Taghıyeva F, Köseoğlu FD, Tuncer SS (01 Eylül 2026) Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case. Ege Tıp Dergisi 65 3 608–611.
IEEE
[1]F. Taghıyeva, F. D. Köseoğlu, ve S. S. Tuncer, “Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case”, ETD, c. 65, sy 3, ss. 608–611, Eyl. 2026, doi: 10.19161/etd.1836093.
ISNAD
Taghıyeva, Fatma - Köseoğlu, Fatoş Dilan - Tuncer, Saniye Sevim. “Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case”. Ege Tıp Dergisi 65/3 (01 Eylül 2026): 608-611. https://doi.org/10.19161/etd.1836093.
JAMA
1.Taghıyeva F, Köseoğlu FD, Tuncer SS. Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case. ETD. 2026;65:608–611.
MLA
Taghıyeva, Fatma, vd. “Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case”. Ege Tıp Dergisi, c. 65, sy 3, Eylül 2026, ss. 608-11, doi:10.19161/etd.1836093.
Vancouver
1.Fatma Taghıyeva, Fatoş Dilan Köseoğlu, Saniye Sevim Tuncer. Synchronous occurrence of chronic myeloid leukemia and chronic lymphocytic leukemia: An uncommon case. ETD. 01 Eylül 2026;65(3):608-11. doi:10.19161/etd.1836093

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