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Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report

Cilt: 65 Sayı: 2 10 Haziran 2026
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Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report

Öz

Ossa cordis is a structure identified in cattle as a component of the cardiac skeleton, whereas in other mammalian species this structure is referred to as cartilago cordis; however, information regarding the presence of cartilago cordis in small mammals, particularly rodents, remains limited. This study reports incidentially observed cartilage-like structures in heart of a Wistar albino and examines their morphological and histological features. Hematoxylin–eosin staining revealed collagen-rich compact areas with cartilage-like matrix, localized near the atrioventricular ring and valve attechment sites, regions exposed to mechanical stress. Although cartilage is not a normal cardiac component, active, cell-mediated calcification processes including differentiation of mesenchymal cells into chondroblasts, cartilage matrix production, and endochondral ossification are recognized in the cardiovascular system. The presence of chondrocyte-like cells, type II and X collagen, and osteogenic proteins in calcified valves supports an osteogenic phenotype in cardiac tissue, suggesting a similar process may occur in rats. These findings imply that cartilago cordis may function as an adaptive structure, contributing to mechanical support, load redistribution, or modulation of conduction–contraction dynamics. In conclusion, this study identifies hyaline cartilage-like formations resembling cartilago cordis in the rat heart, providing a novel perspective on interspecies anatomical variation and cardiac mineralization, and highlighting the potential universality and biological significance of heterotopic cartilage and bone formation in the heart.

Anahtar Kelimeler

Etik Beyan

This case report presents an incidental finding detected in an adult, 4-year-old, female Wistar albino rat weighing 210–230 g. The rat was originally used in a seperate research Project focused on comparing paraffin and JB-4 embedding techniques in light microscopy. In that study, the heart tissue was not part of the intended analysis; however, during routine tissue processing, a cartilaginous structure was incidentially observed in the heart, which was unrelated to the original experimental aim. Throughout the experimental period, the rat was maintained under standard laboratory conditions with a 12-hour light/12-hour dark cycle and provided ad libitum access to water and pellet chow. Ethical approval for the original study was granted by the local Animal Experiments Ethics Committee (Approval No: 65202830-050.04.04.-13, dated 05.03.2025).

Kaynakça

  1. Dyce KM, Sack WO, Wensing CJG. Textbook of veterinary anatomy. 5th ed. Elsevier Saunders; 2017.
  2. Nasoori A. Formation, structure, and function of extra-skeletal bones in mammals. Biol Rev 2020;95(4):986–1019. https://doi.org/10.1111/brv.12597
  3. Best A, Egerbacher M, Swaine S, Perez W, Alibhai A, Rutland P, Rutland CS. Anatomy, histology, development and functions of Ossa cordis: A review. Anat Histol Embryol 2022;51(6):683–695. https://doi.org/10.1111/ahe.12817
  4. Trainini JC, Lowenstein J, Beraudo M, Wernicke M, Trainini A, Llabata VM, Carreras CF. Myocardial torsion and cardiac fulcrum. Morphologie 2021;105(348):15–23. https://doi.org/10.1016/j.morpho.2020.06.010
  5. Egerbacher M, Weber H, Hauer S. Bones in the heart skeleton of the otter (Lutra lutra). J Anat 2000;196:485–491. https://doi.org/10.1046/j.1469-7580.2000.19630485.x
  6. Gopalakrishnan G, Blevins WE, Van Alstine WG. Osteocartilaginous metaplasia in the right atrial myocardium of healthy adult sheep. J Vet Diagn Invest 2007;19(5):518–524. https://doi.org/10.1177/104063870701900509
  7. von Gise A, Pu WT. Endocardial and epicardial epithelial-to-mesenchymal transitions in heart development and disease. Circ Res 2012;110(12):1628–1645. https://doi.org/10.1161/CIRCRESAHA.111.259960
  8. Towler DA, Linda DD. Vascular calcification: A perspective on an imminent epidemic. Circ Res 2011;108(11):1378–1380. https://doi.org/10.1161/CIRCRESAHA.111.243022

Ayrıntılar

Birincil Dil

İngilizce

Konular

Patoloji

Bölüm

Olgu Sunumu

Yazarlar

Yayımlanma Tarihi

10 Haziran 2026

Gönderilme Tarihi

13 Aralık 2025

Kabul Tarihi

30 Aralık 2025

Yayımlandığı Sayı

Yıl 2026 Cilt: 65 Sayı: 2

DOI

https://doi.org/10.19161/etd.1841533

IZ

https://izlik.org/JA66CC25GB

Kaynak Göster

RIS / Bibtex
APA
Hamutoğlu, R., & Ünver Saraydin, S. (2026). Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report. Ege Tıp Dergisi, 65(2), 336-339. https://doi.org/10.19161/etd.1841533
AMA
1.Hamutoğlu R, Ünver Saraydin S. Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report. ETD. 2026;65(2):336-339. doi:10.19161/etd.1841533
Chicago
Hamutoğlu, Rasim, ve Serpil Ünver Saraydin. 2026. “Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report”. Ege Tıp Dergisi 65 (2): 336-39. https://doi.org/10.19161/etd.1841533.
EndNote
Hamutoğlu R, Ünver Saraydin S (01 Haziran 2026) Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report. Ege Tıp Dergisi 65 2 336–339.
IEEE
[1]R. Hamutoğlu ve S. Ünver Saraydin, “Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report”, ETD, c. 65, sy 2, ss. 336–339, Haz. 2026, doi: 10.19161/etd.1841533.
ISNAD
Hamutoğlu, Rasim - Ünver Saraydin, Serpil. “Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report”. Ege Tıp Dergisi 65/2 (01 Haziran 2026): 336-339. https://doi.org/10.19161/etd.1841533.
JAMA
1.Hamutoğlu R, Ünver Saraydin S. Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report. ETD. 2026;65:336–339.
MLA
Hamutoğlu, Rasim, ve Serpil Ünver Saraydin. “Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report”. Ege Tıp Dergisi, c. 65, sy 2, Haziran 2026, ss. 336-9, doi:10.19161/etd.1841533.
Vancouver
1.Rasim Hamutoğlu, Serpil Ünver Saraydin. Histological evaluatıon of structures similar to the cartilago cordis in the rat heart: A case report. ETD. 01 Haziran 2026;65(2):336-9. doi:10.19161/etd.1841533

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