OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ

Gülçin Başdemir; Özden Öz Ersoy; Fikri Öztop

EN TR

THE CORRELATION OF MDR/P-gp PHENOTYPE AND DIFFERENTIATION OF OSTEOSARCOMA

Öz

Recent experimental studies on osteosarcomas (OS) have postulated that similar to other malignancies, pglycoprotein (P-gp) positivity is directly correlated with differentiation. Therefore, it has been hypothesized that Pgp cannot be a marker of poor prognosis. In this study, the distribution of P-gp positivity in different areas of OSs with variable differentiation pathways is assessed and its relationship with differentiation is questioned. The cases, which have received the diagnosis of OS in our department between 1984-2000, were included in the study. A total of 337 sections were immunohistochemically stained for P-gp, which consisted of 81 primary surgical materials, 82 biopsies, 13 lung specimens, one axillary lymph node and one rib metastasis, and three local recurrence materials. The P-gp staining patterns were scored between 0 and 6 on a total of 544 areas with different differentiation pathways. Our results have shown that P-gp expression of OSs has no correlation with the matrix content and differentiation. Furthermore, the analysis of the histological subtypes did not present any differences in the staining patterns. İn conclusion, despite the previous reports demonstrating correlation of this protein with differentiation, İt appears that P-gp staining of OSs is an independent factor.

Anahtar Kelimeler

P-Glycoprotein, multiple drug resistance, osteosarcoma

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Gülçin Başdemir

Özden Öz Ersoy

Fikri Öztop

Yayımlanma Tarihi

1 Haziran 2002

Gönderilme Tarihi

1 Haziran 2002

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2002 Cilt: 41 Sayı: 2

IZ

https://izlik.org/JA36CH26YJ

Kaynak Göster

RIS / Bibtex

APA

Başdemir, G., Ersoy, Ö. Ö., & Öztop, F. (2002). OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ. Ege Tıp Dergisi, 41(2), 67-75. https://izlik.org/JA36CH26YJ

AMA

1.Başdemir G, Ersoy ÖÖ, Öztop F. OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ. ETD. 2002;41(2):67-75. https://izlik.org/JA36CH26YJ

Chicago

Başdemir, Gülçin, Özden Öz Ersoy, ve Fikri Öztop. 2002. “OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ”. Ege Tıp Dergisi 41 (2): 67-75. https://izlik.org/JA36CH26YJ.

EndNote

Başdemir G, Ersoy ÖÖ, Öztop F (01 Haziran 2002) OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ. Ege Tıp Dergisi 41 2 67–75.

IEEE

[1]G. Başdemir, Ö. Ö. Ersoy, ve F. Öztop, “OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ”, ETD, c. 41, sy 2, ss. 67–75, Haz. 2002, [çevrimiçi]. Erişim adresi: https://izlik.org/JA36CH26YJ

ISNAD

Başdemir, Gülçin - Ersoy, Özden Öz - Öztop, Fikri. “OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ”. Ege Tıp Dergisi 41/2 (01 Haziran 2002): 67-75. https://izlik.org/JA36CH26YJ.

JAMA

1.Başdemir G, Ersoy ÖÖ, Öztop F. OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ. ETD. 2002;41:67–75.

MLA

Başdemir, Gülçin, vd. “OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ”. Ege Tıp Dergisi, c. 41, sy 2, Haziran 2002, ss. 67-75, https://izlik.org/JA36CH26YJ.

Vancouver

1.Gülçin Başdemir, Özden Öz Ersoy, Fikri Öztop. OSTEOSARKOMDA MDR/P-gp FENOTİPİNİN DİFERANSİYASYON İLE İLİŞKİSİ. ETD [Internet]. 01 Haziran 2002;41(2):67-75. Erişim adresi: https://izlik.org/JA36CH26YJ