SIÇANLARDA KİMYASAL SİMPATEKTOMİNİN NÖROTOKSİK ETKİSİ

Cilt: 45 Sayı: 1 1 Mart 2006
  • Ayşe Tuç
  • İbrahim Tuğlu
  • Altuğ Yavaşoğlu
  • Tuncay Varol
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THE NEUROTOXIC EFFECT OF CHEMICAL SYMPATHECTOMY IN THE RAT

Abstract

Objective: Guanethidine is an antihypertensive drug which can produce structural alterations on the vessels of the brain. It has also been used for the purpose of chemical sympathectomy in experimental studies. However there is little, if any, information on the neurotoxic effects of the drug except the regions where they exert their primary effects. Therefore we have conducted this study to histologically investigate the effects of guanethidine in regions most susceptible to neurotoxicity. Material and Methods: Desympathization was induced in mature rats by daily single intraperitoneal injection of 10 mg/kg of guanethidine for 30 days. Same volume of saline was injected the same way to control animals. Rats were euthanized with cardiac perfusion and brains were removed to be fixed in formaline and embedded in paraffin. Serial sections were stained with H&E and examined under light microscope. Cell density was measured from selected vulnarable regions of the brain by morphometric methods. Findings: We found an increase in pericytoplasmic area, nuclear condensation and picnosis-like changes in guanethidine group. There were no clear pathologic alterations in the brain stem, cerebellum, cerebral cortex and hippocampus in the control group. Results and Conclusion: Guanethidine needs to be used with caution clinically due to its side effects and experimentally due to its possible neurotoxic effects which may confound interpretation of the findings. Further studies are required to uncover the neurotoxic effects of the drug.

Keywords

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Ayşe Tuç

İbrahim Tuğlu

Altuğ Yavaşoğlu

Tuncay Varol

Yayımlanma Tarihi

1 Mart 2006

Gönderilme Tarihi

1 Mart 2006

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2006 Cilt: 45 Sayı: 1

IZ

https://izlik.org/JA99JD89MR

Kaynak Göster

RIS / Bibtex
Vancouver
1.Ayşe Tuç, İbrahim Tuğlu, Altuğ Yavaşoğlu, Tuncay Varol. SIÇANLARDA KİMYASAL SİMPATEKTOMİNİN NÖROTOKSİK ETKİSİ. ETD [Internet]. 01 Mart 2006;45(1):25-30. Erişim adresi: https://izlik.org/JA99JD89MR

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