PROINFLAMATUAR SİTOKİNLER : PLEVRAL EFFÜZYONLARIN AYRIMLANMASINDA YARARLIMIDIR?

Cilt: 45 Sayı: 1 1 Mart 2006
  • Çiğdem Yenisey
  • Serir Aktoğu
  • Sabri Kalenci
  • F. Onur Erer
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PROINFLAMMATORY CYTOKINES : ARE THEY USEFULL IN DIFFERENTIAL DIAGNOSIS OF PLEURAL EFFUSIONS?

Abstract

Interleukin 1- beta (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF- α) were measured in pleural fluid from 128 patients with pleural effusion in order to evaluate the diagnostic utility of these cytokines. We studied 42 patients with malignant, 23 patients with parapneumonic, 38 patients with tuberculous, and 25 patients with transudative pleural effusion. Patients samples were taken applied to the Yenişehir Suat Seren Chest Hospital at the clinics 9B an 4B were diagnosed suffereing from pleural effusion. Cytokines were measured by chemiluminescent enzyme immunometric assay using BIODPC commercial kits via IMMULATE 2000 hormone analyzer. In exudative samples the difference between the pleural fluid and serum, IL-1β, IL-6, and TNF-α levels were found statistically important. Only, IL-6 levels were found dramatically different between serum and pleural fluid in transudative samples. Mean IL-6 and TNF-α levels were significantly higher in pleural fluid than in serum in all three groups of patients (malignant, parapneumonic, and tuberculosis). But, the highest mean level of IL-6 and TNF-α were found in tuberculous pleural fluid. In conclusion, low serum IL-6 and high pleural fluid IL-6 can distinguish transudates due to heart failure from exudates. Also, serum and pleural fluid IL-6 could be useful as a complementary marker in the differential diagnosis of two most common types of exudates (tuberculous and malignant) and TNF-α in the serum and pleural fluid could be useful confirmation differential diagnosis of tuberculous and malignant effusions.

Keywords

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Çiğdem Yenisey

Serir Aktoğu

Sabri Kalenci

F. Onur Erer

Yayımlanma Tarihi

1 Mart 2006

Gönderilme Tarihi

1 Mart 2006

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2006 Cilt: 45 Sayı: 1

IZ

https://izlik.org/JA92CK35XR

Kaynak Göster

RIS / Bibtex
Vancouver
1.Çiğdem Yenisey, Serir Aktoğu, Sabri Kalenci, F. Onur Erer. PROINFLAMATUAR SİTOKİNLER : PLEVRAL EFFÜZYONLARIN AYRIMLANMASINDA YARARLIMIDIR? ETD [Internet]. 01 Mart 2006;45(1):19-24. Erişim adresi: https://izlik.org/JA92CK35XR

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