Antibiyotik tedavisine ek olarak oktreotid uygulanması deneysel peritonit modelinde ultrafiltrasyon yetmezliğini engelleyebilir

Cilt: 50 Sayı: 3 1 Eylül 2011
  • Hür E
  • Ertilav M
  • Bozkurt D
  • Arda B
  • Sözmen E Y
  • Şen S
  • Başçı A
  • - Akçiçekf
  • Duman S
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Octreotide in addition to antibiotic treatment may prevent ultrafiltration failure in experimental peritonitis model

Abstract

Aim: Ultrafiltration (UF) failure is usually associated with peritoneal dialysis (PD) peritonitis. Octreotide (OCT) has antiproliferative effects on many cells. The present study aimed to investigate the effect of OCT on antibiotic treatment of peritonitis. Material and Methods: Forty non-uremic female rats, were divided into four groups receiving no treatment (Control, n=12); a peritonitis group which received 1.5ml suspension of E.Coli (107CFU/ml)(E.Coli, n=12); an antibiotic group which received 1.5ml suspension of E.Coli (107CFU/ml)+antibiotic (AB, cefazoline 50 mg/kg)(E.Coli+AB, n=8) and a OCT group which received E.Coli+AB+50µg/kg OCT intraperitoneally (E.Coli+AB+OCT, n=8). After six hours, a one-hour PET was performed with 3.86% glucose PD solution; and D1/D0 glucose, UF volume, dialysate cell count, dialysate protein and cytokines were determined. A bacteriological culture was performed for all dialysates. Results: E.Coli exposure causes peritonitis with an increase in permeability leading to UF failure. Antibiotic treatment partially preserves UF capacity. Peritonitis induced UF failure which was completely prevented by AB plus OCT treatment. Both treatments led to attenuation of UF failure by inhibiting local TGF b-1 production and decreasing dialysate cell count. Conclusion: In conclusion, adding OCT in dialysate, may help to prevent peritonitis induced UF failure and preserve peritoneal viability by inhibiting acute cytokines over-expression and cell infiltration during peritonitis. In the long-term, it can decrease peritoneal fibrosis.

Keywords

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Hür E

Ertilav M

Bozkurt D

Arda B

Sözmen E Y

Şen S

Başçı A

- Akçiçekf

Duman S

Yayımlanma Tarihi

1 Eylül 2011

Gönderilme Tarihi

1 Eylül 2011

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 1970 Cilt: 50 Sayı: 3

IZ

https://izlik.org/JA99RL76FX

Kaynak Göster

RIS / Bibtex
Vancouver
1.Hür E, Ertilav M, Bozkurt D, Arda B, Sözmen E Y, Şen S, Başçı A, - Akçiçekf, Duman S. Antibiyotik tedavisine ek olarak oktreotid uygulanması deneysel peritonit modelinde ultrafiltrasyon yetmezliğini engelleyebilir. ETD [Internet]. 01 Eylül 2011;50(3):167-73. Erişim adresi: https://izlik.org/JA99RL76FX

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