Ege Üniversitesi Hastanesi'ne başvuran santral sinir sistemi enfeksiyonu olgularında saptanan viral etkenler

Cilt: 53 Sayı: 2 1 Haziran 2014
  • Soylar M
  • Altuğlu İ
  • Sertöz R
  • Aydın D
  • Akkoyun F
  • Zeytinoğlu A
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Viral agents in patients with central nervous infections admitted to Ege University Hospital

Abstract

Aim: Central Nervous system (CNS) infections require a rapid diagnosis and treatment approach due to their potential of rapid progression and the possibility of permanent neurological damage. In this study, viral agents detected by nucleic acid tests in the cerebrospinal fluid samples of patients with a suspicion of viral CNS infection were sent to Medical Microbiology Laboratory of Ege University Hospital and evaluated. Materials and Methods: A total number of 289 CSF samples submitted to Medical Microbiology Laboratory from January 2012 to December 2012 for viral nucleic acid testing were evaluated retrospectively. One hundred ninety eight CSF samples were tested for HSV DNA (HSV LightCycler ½ Qual Kit, Roche, Germany), 46 samples for CMV DNA (CMV Fluorion QNP 3.0 Real-Time PCR, İontek, Turkey), 20 samples for EBV DNA (Lightmix Kit Epstein-Barr virus, TIB MOLBIOL, Germany) and 25 samples for Enterovirus RNA (GeneXpert Xpert EV, Cepheid, USA). Results: One hundred fifty three patients were females and 136 were males, ages ranging from 0 to 88 (median age 39) years. HSV DNA was detected by nucleic acid testing in two of the 198 patients (1%), CMV DNA in one of the 46 patients (2%), EBV DNA three of the 20 patients (15%) and enterovirus RNA in one of the 25 patients (4%). Conclusion: Even though CNS infections are not rare, the incidence is not clearly established. Due to high mortality rate and potential of neurological damage, they are extremely important. Even though the etiology is unknown in many cases, the development of molecular techniques has increased the detection rate of viral agents.

Keywords

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Soylar M

Altuğlu İ

Sertöz R

Aydın D

Akkoyun F

Zeytinoğlu A

Yayımlanma Tarihi

1 Haziran 2014

Gönderilme Tarihi

1 Haziran 2014

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2014 Cilt: 53 Sayı: 2

DOI

https://doi.org/10.19161/etd.344054

IZ

https://izlik.org/JA69SU89KA

Kaynak Göster

RIS / Bibtex
Vancouver
1.Soylar M, Altuğlu İ, Sertöz R, Aydın D, Akkoyun F, Zeytinoğlu A. Ege Üniversitesi Hastanesi’ne başvuran santral sinir sistemi enfeksiyonu olgularında saptanan viral etkenler. ETD. 01 Haziran 2014;53(2):65-70. doi:10.19161/etd.344054

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Sağlık Bilimlerinde Değer

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Santral Sinir Sistemi Enfeksiyonunda Viral Etkenlerin Gerçek Zamanlı PCR Yöntemi ile Saptanması

Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi

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