Koroner arter kalsiyum skoru kırmızı kan hücresi dağılım genişliği ve ortalama trombosit hacmi ile ilişkilidir

Cihan Altın; Mustafa Yılmaz; Esin Gezmiş; Haldun Müderrisoğlu

doi:10.19161/etd.465086

EN TR

Coronary artery calcium score is associated with red blood cell distribution width and mean platelet volume

Abstract

Aim: In this paper, it is aimed to investigate red blood cell distribution width (RDW), mean platelet volume (MPV) and coronary artery calcium scores (CACS) in patients with and without coronary artery disease (CAD) detected by coronary computed tomography angiography (CCTA).

Materials and Methods: Clinical records of 172 patients who underwent CCTA due to the presence of angina-like symptoms were retrospectively investigated. Clinical characteristics, risk factors for CAD, CACS and biochemical parameters including RDW and MPV were recorded.

Results: Mean MPV (7.95 ±1.57 fL vs. 7.12±1.26 fL, p<0.001) and RDW (15.36±1.15% vs 14.37±2.01%; p<0.001) levels were significantly higher in patients with CAD (n=85) than in those with normal coronary arteries (n=87). CACS is positively corralated with age (r=0.339, p<0.001), fasting glucose (r=0.223, p=0.003), C-reactive protein (r=0.294, p<0.001), RDW (r=0.157, p=0.04) and MPV (r=0.221, p=0.004). On multivariate logistic regression analysis, CACS [odds ratio (OR): 1.005; 95% confidence interval (CI): 1.002-1.008; p=0.001] and MPV [OR: 1.410; 95% CI: 1.069-1.860; p=0.015] were shown to be one of the independent predictors for CAD detected by CCTA.

Conclusion: RDW and MPV were increased in patients with CAD detected by CCTA. These parameters were possitively corralated with CACS which is a well-known indicator for CAD. Because several factors may affect these parameters further prospective studies are needed to confirm our results.

Keywords

Red blood cell distribution width,mean platelet volume,coronary artery calcium score,coronary artery disease,coronary computed tomography angiography.

Koroner arter kalsiyum skoru kırmızı kan hücresi dağılım genişliği ve ortalama trombosit hacmi ile ilişkilidir

Öz

Amaç: Bu çalışmada, koroner bilgisayarlı tomografik anjiyografi (KBTA) ile saptanan koroner arter hastalığı (KAH) ve koroner arter kalsiyum skorunun (KAKS) kırmızı kan hücresi dağılım genişliği (RDW) ve ortalama trombosit hacmi (MPV) arasındaki ilişkinin değerlendirilmesi amaçlandı.

Gereç ve Yöntem: Anjina veya benzeri semptomlar nedeniyle 64 kesitli KBTA uygulanan 172 hastanın tıbbi kayıtları geriye dönük olarak incelendi. Hastaların klinik özellikleri, risk faktörleri, KAKS’ı da içeren KBTA sonuçları, RDW, MPV değerlerini de içeren biyokimyasal ve hematolojik parametreleri kaydedildi.

Bulgular: Çalışma popülasyonu KBTA sonuçlarına göre KAH (n=85) ve normal koroner arter (NKA) (n=87) olmak üzere iki gruba ayrıldı. Ortalama RDW (%15,36±1,15’e karşı %14,37±2,01; p<0,001) ve MPV (7,95 ± 1,57 fL’e karşı 7,12±1,26 fL, p<0,001) seviyeleri KAH grubunda NKA grubuna göre anlamlı olarak yüksek saptandı. KAKS ile yaş (r=0,339, p<0,001), açlık kan şekeri (r=0,223, p=0,003), C-reaktif protein (r=0,294, p<0,001), RDW (r=0,157, p=0,04) ve MPV (r=0,221, p=0,004) arasında pozitif korelasyon saptandı. Yapılan çok değişkenli lojistik regresyon analizinde KAKS [odds oranı (OR): 1,005; %95 güven aralığı (CI): 1,002-1,008; p=0,001] ve MPV [OR: 1,410; %95 CI: 1,069-1.860; p=0.015] KBTA ile saptanan KAH’ın bağımsız risk faktörleri arasında saptandı.

Sonuç: RDW ve MPV KAH grubunda anlamlı olarak daha yüksek saptanmıştır. Koroner aterosklerozun iyi bir göstergesi olan KAKS ile bu parametreler arasında pozitif bir korelasyon gösterilmiştir. MPV ve RDW düzeylerinin çok çeşitli faktörlerden etkilenebileceği de düşünülürse bu konuda geniş kapsamlı ileri prospektif çalışmalara ihtiyaç duyulmaktadır.

Anahtar Kelimeler

Koroner bilgisayarlı tomografik anjiyografi,koroner arter hastalığı,koroner arter kalsiyum skoru,kırmızı kan hücresi dağılım genişliği,ortalama trombosit hacmi.

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Cihan Altın ^*
0000-0002-3996-5681
Türkiye

Mustafa Yılmaz
0000-0002-2557-9579
Türkiye

Esin Gezmiş
0000-0002-1001-6028
Türkiye

Haldun Müderrisoğlu
0000-0002-9635-6313
Türkiye

Yayımlanma Tarihi

20 Eylül 2019

Gönderilme Tarihi

20 Nisan 2018

Kabul Tarihi

6 Temmuz 2018

Yayımlandığı Sayı

Yıl 2019 Cilt: 58 Sayı: 3

DOI

https://doi.org/10.19161/etd.465086

IZ

https://izlik.org/JA45WW68TA

Kaynak Göster

RIS / Bibtex

Vancouver

1.Cihan Altın, Mustafa Yılmaz, Esin Gezmiş, Haldun Müderrisoğlu. Koroner arter kalsiyum skoru kırmızı kan hücresi dağılım genişliği ve ortalama trombosit hacmi ile ilişkilidir. ETD. 01 Eylül 2019;58(3):222-8. doi:10.19161/etd.465086