Role of radiotherapy in Masaoka stage II and III thymomas - single center experience

Esra Korkmaz Kıraklı; Sevilay Erdem; Mediha Tülin Bozkurt; Hasan Yılmaz

doi:10.19161/etd.468605

EN TR

Role of radiotherapy in Masaoka stage II and III thymomas - single center experience

Abstract

Aim: Thymomas are rare neoplasms. Complete surgical resection is the cornerstone of the treatment. The role of adjuvant radiotherapy (RT) in Masaoka stage II disease is controversial, but in more advanced stages and the role of radical RT in inoperable cases are clear. This study is conducted to evaluate local control, relapse free survival and overall survival rates in Masaoka stage II and III thymoma patients after adjuvant or radical RT.

Materials and Methods: The medical records of thymoma patients who were treated and completed their RT course between January 2010 and August 2016 in a single center were evaluated retrospectively.

Results: Twenty-two patients were available for analysis. Treatment planning was adjuvant in 18 patients and radical in 5 patients. Median age at diagnosis was 59 (50-62). Type of resection was R0 in all cases. The adjuvant RT dose was 50 Gy; radical RT dose was 60-66 Gy. The most common acute toxicity was grade 1 pneumonitis which was reported in 9 patients (39%). Grade 2 acute pneumonitis was experienced by 3 patients (13%), grade 2 acute esophagitis was experienced by 2 patients (9%). One patient had late grade 3 esophageal toxicity. Follow-up time ranged from 6 to 99 months, median 18 months, local control rate was 100%, relapse free survival (RFS) was 96%, cancer specific survival was 96%, 2 years overall survival (OS) was 83%.

Conclusion: Although our results seem to be in concordance with the literature, longer follow-up is needed to be able to make a conclusion in terms of LC, RFS and OS, since thymoma has an indolent course with low relapse rate and long RFS.

Keywords

Thymoma,radiotherapy,stage II,stage III.

Masaoka evre II ve III timomada radyoterapinin rolü - tek merkez deneyimi

Öz

Amaç: Timomalar oldukça nadir tümörlerdir. Tam rezeksiyon tedavinin ana öğesidir. Adjuvan radyoterapinin (RT) rolü Masaoka evre II hastalıkta tartışmalıyken, daha ileri evrelerde ve inoperabl olgularda nettir. Bu çalışma, evre II-III timoma olgularında adjuvan veya radikal RT sonrası lokal kontrol, yinelemesiz sağ kalım ve genel sağ kalım (GS) sonuçlarını araştırmak için planlandı.

Gereç ve Yöntem: Ocak 2010-Ağustos 2016 arasında timoma tanısıyla RT uygulanan olguların medikal verileri geriye dönük olarak incelendi.

Bulgular: Adjuvan RT uygulanan 18 ve radikal RT uygulanan 5, toplam 23 evre II-III olgu analizlere dahil edildi. Ortanca yaş 59 (50-62) idi. Opere olguların tümünde rezeksiyon R0 şeklindeydi. Adjuvan RT dozu 50 Gy, radikal RT dozu 60-66 Gy idi. En sık izlenen toksisite 9 olguda (%39) gelişen derece 1 pnömoni idi. Derece 2 pnömoni 3 olguda (%13), derece 2 özofajit 2 olguda (%9) izlenirken, 1 olguda geç dönem özofajial toksisite izlendi. İzlem süresi ortanca 18 aydı (6-99 ay). Lokal kontrol oranı %100, yinelemesiz sağ kalım oranı %96, kansere özgü sağ kalım %96, 2 yıllık GS oranı %83’tü.

Sonuç: Sonuçlarımız literatür ile uyumlu görünmesine rağmen, timomanın yineleme oranı düşük ve yinelemesiz sağ kalımı uzun bir hastalık olması nedeniyle lokal kontrol, yinelemesiz sağ kalım ve GS sonuçlarımızla ilgili yorum yapabilmemiz için daha uzun izlem süresine ihtiyaç duyulmaktadır.

Anahtar Kelimeler

Timoma,radyoterapi,evre II,evre III.

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Esra Korkmaz Kıraklı ^*
0000-0003-4557-2865
Türkiye

Sevilay Erdem
0000-0002-1380-3158
Türkiye

Mediha Tülin Bozkurt
0000-0002-3728-425X
Türkiye

Hasan Yılmaz
0000-0002-0581-1166
Türkiye

Yayımlanma Tarihi

20 Eylül 2019

Gönderilme Tarihi

14 Mayıs 2018

Kabul Tarihi

4 Temmuz 2018

Yayımlandığı Sayı

Yıl 2019 Cilt: 58 Sayı: 3

DOI

https://doi.org/10.19161/etd.468605

IZ

https://izlik.org/JA36CZ47BN

Kaynak Göster

RIS / Bibtex

Vancouver

1.Esra Korkmaz Kıraklı, Sevilay Erdem, Mediha Tülin Bozkurt, Hasan Yılmaz. Role of radiotherapy in Masaoka stage II and III thymomas - single center experience. ETD. 01 Eylül 2019;58(3):208-14. doi:10.19161/etd.468605

Cited By

Thymoma radiotherapy: a retrospective multicentre study

Anatolian Current Medical Journal

https://doi.org/10.38053/acmj.1298365