Current drug treatment in fibromyalgia
Abstract
Fibromyalgia (FM), a disorder characterized by widespread chronic musculoskeletal pain, fatigue and dysfunction. Together with the genetic predisposition, it may be effective in the emergence of the disease in environmental and psychological factors. The aim of drug therapy in fibromyalgia is to reduce pain and improve other symptoms. Non-pharmacological therapies like cognitive behavioral therapies, training, exercise and pharmacologic therapies need versatile approach. Fibromyalgia treatment is performed by a single specialist or a team (rheumatologist, neurologist, and psychiatrist) according to the number and variety of the patient's symptoms. In pharmacological treatment, antidepressants (amitriptyline, cyclobenzaprine, duloxetine, milnacipran) and anticonvulsants (pregabalin, gabapentin) are most commonly used. International fibromyalgia treatment recommendations focus mainly on aerobic exercise, cognitive-behavioral therapy and drug therapy such as amitriptyline
Keywords
Kaynakça
- Kia S, Choy E. Uptodate on treatment guideline in fibromyalgia syndrome with focus on pharmacology. Biomedicines 2017,5(2). pii: E20. doi: 10.3390/biomedicines5020020.
- Clauw D. Fibromyalgia a clinical review. JAMA 2014;311(15):1547-55.
- Liu Y, Qian C,Yang M, Treatment Patterns Associated with ACR-Recommended Medications in the Management of Fibromyalgia in the United States. J Manag Care Spec Pharm 2016;22(3):263-71.
- Theoharides TC, Tsilioni I, Arbetman L, et al. Fibromyalgia syndrome in need of effective treatments. J Pharmacol Exp Ther 2015;355(2):255-63.
- Hauser W, Abline J, Perrot S, Fitzcharless MA. Management of fibromyalgia: key messaes from evidence-based guidelines. Pol Arch Intern Med 2017;127(1):47-56.
- Borchers AT, Gershwin ME. Fibromyalgia: a critical and comprehensive review. Clinic Rev Allerg Immunol 2015;49(2):100-51.
- Walitt B, Urruita G, Nishishinya MB, Cantrell SE, Hauser W. Selective serotonin reuptake inhibitors for fibromyalgia syndrome. Cochrane Database of Systematic Reviews, 2015 Jun 5;(6): CD011735. doi: 10.1002/14651858.CD011735.
- Moldofsky H, Harris HW, Archambault WT, Kwong T, Lederman S. Effects of bedtime very low dose cyclobenzaprine on symptoms and sleep physiology in patients with fibromyalgia syndrome: a double-blind randomized placebo-controlled study. J Rheumatol. 2011;38(12):2653-63.
Ayrıntılar
Birincil Dil
Türkçe
Konular
-
Bölüm
Diğer
Yazarlar
Seval Pehlevan
*
0000-0003-3800-7868
Türkiye
Yayımlanma Tarihi
25 Ekim 2019
Gönderilme Tarihi
19 Ekim 2018
Kabul Tarihi
15 Ağustos 2019
Yayımlandığı Sayı
Yıl 1970