Öz
Aim: To evaluate epidemiologic features and survival outcomes of 3379 patients treated with the diagnosis of carcinoma of the corpus uteri (CC) in Ege University Hospital (EUH) between 1992-2017 and compare them with the literature.
Materials and Methods: Data recorded to CANREG-4 program in EUH between 1992-2017 by EU Fight Against Cancer Research and Application Center (EUKAM) were grouped according to WHO and SEER systems. For statistical analysis, Chi-square method and general linear modeling and Kaplan-Meier analysis were performed. In Kaplan-Meier analysis, Log Rank (Mantel-Cox), Breslow (Generalized Wilcxon) and Tarone-Ware methods were used. p<0.05 was accepted as significant.
Results: Carcinoma of the corpus uteri was the most common cancer among gynecologic cancers (41.6%). It was mostly seen at the ages between 50-59. The most common histological subtypes were epithelial tumors and endometrioid carcinoma in this group. The disease is usually localized to the uterus at the time of diagnosis (70.6%). Median survival was 120 months. 5 year overall survival rate was 68.9% and 10 year overall survival rate was 66%.
Conclusion: Carcinoma of the corpus uteri is the most common gynecologic cancer. Twenty-five years data of our hospital was found similar with the literature in regard to demographic, histopathologic features and survival outcomes.
Anahtar Kelimeler
Carcinoma of the corpus uteri epidemiology incidence mortality overall survival
Kaynakça
- https://hsgm.saglik.gov.tr/depo/birimler/kanser-db/istatistik/2014-RAPOR._uzuuun.pdf.
- Cancer report 2010. Ed Tuncer Am, Moore M, Qiazo YL, Yoo KY, Tijama K, Özgül N, Gültekin M. Asian pacific organization for cancer prevention (APOCP) İstanbul 2010.
- Jemal A, S,egel R, Ward E. Cancer statistics, 2008. CA Cancer J Clin 2008; 58: 71-96.
- Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65: 87.
- Galaal K, Donkers H, Bryant A, Lopes AD. Laparoscopy versus laparotomy for themanagement of early stage endometrial cancer. Cochrane Database of Systematic Reviews 2018, Issue 10. Art. No.: CD006655. DOI: 10.1002/14651858.CD006655.
- Amant F, Moerman P, Timmerman D, Limbergen EV, Vergote I. Endometrial cancer. Lancet 2005; 366: 491-505.
- Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2015, National Cancer Institute.
- Alektiar KM, McKee A, Lin O. Is there a difference in outcome between stage I-II endometrial cancer of papillary serous/clear cell and endometrioid FIGO grade 3 cancer? Int J Radiat Oncol Biol Phys. 2002; 54: 79–85.
- Cirisano FD, Robboy SJ, Dodge RK. Epidemiopathologic and surgicopathologic findings of papillary serous and clear cell endometrial cancers when compared to endometrioid carcinoma. Gynecol Oncol. 1999; 74: 385–94.
- Kosary CL. FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973–1987 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina. Semin Surg Oncol. 1994; 10: 31–46.
- Tejerizo-García A, Jiménez-López JS, Muñoz-González JL, Bartolomé-Sotillos S, Marqueta-Marqués L, López-González G, Gómez JF. Overall survival and disease-free survival in endometrial cancer: prognostic factors in 276 patients. Onco Targets Ther. 2013; 9: 1305-13.
Öz
Amaç: Ege Üniversitesi Hastanesinde 1992-2017 arası kanser tanı ve tedavisi yapılan 3379 korpus uteri kanserinin epidemiyolojik ve sağ kalım özelliklerini analiz etmek ve sonuçları literatürle karşılaştırmaktır.
Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Araştırma ve Uygulama Merkezi tarafından toplanan korpus uteri kanseri verileri CANREG özel bilgisayar programına kayıt edilmiş, DSÖ ve SEER sistemleri temelinde gruplanarak analizler yapılmıştır. İstatistik analizlerde Ki-kare, General Linear Model, Kaplan Meier sağ kalım analizleri uygulanmıştır. Kaplan Meier Sağ kalım analizinde Log Rank (Mantel-Cox), Breslow (Generalized Wilcoxon) ve Tarone-Ware istatistikleri kullanılmıştır. İstatistik analizlerde p<0.05 istatistiksel olarak anlamlı kabul edilmiştir.
Bulgular: Korpus uteri kanseri jinekolojik kanserler arasında en sık görülen kanser (%41,6) olarak saptanmıştır. En sık görüldüğü yaş grubu 50-59’dur. Histolojik alt tip olarak en sık epitelyal tümörler ve bu grupta da endometrioid karsinom görülmüştür. Daha nadir görülen mezenkimal tümörlerden en sık stromal sarkom görülürken miks tip tümörlerde miks müllerian tümör görülmektedir. Hastalık tanı anında genellikle lokalize tümördür (%70,6). Ortalama sağ kalım süresi 120 ay olarak saptanmıştır. Genel sağ kalım oranı beş yıllık %68,9 ve 10 yıllık ise %66 olarak bulunmuştur.
Sonuç: Jinekolojik kanserler arasında en sık korpus uteri kanseri görülür. Hastanemizin 25 yıllık verileri değerlendirildiğinde demografik verilerin ve histopatolojik bulguların literatür ile uyumlu olduğu, sağ kalım sürelerinin ise gelişmiş ülkeler ile benzer olduğu görülmektedir.
Anahtar Kelimeler
Korpus uteri kanseri epidemiyoloji insidans mortalite genel sağ kalım
Kaynakça
- https://hsgm.saglik.gov.tr/depo/birimler/kanser-db/istatistik/2014-RAPOR._uzuuun.pdf.
- Cancer report 2010. Ed Tuncer Am, Moore M, Qiazo YL, Yoo KY, Tijama K, Özgül N, Gültekin M. Asian pacific organization for cancer prevention (APOCP) İstanbul 2010.
- Jemal A, S,egel R, Ward E. Cancer statistics, 2008. CA Cancer J Clin 2008; 58: 71-96.
- Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65: 87.
- Galaal K, Donkers H, Bryant A, Lopes AD. Laparoscopy versus laparotomy for themanagement of early stage endometrial cancer. Cochrane Database of Systematic Reviews 2018, Issue 10. Art. No.: CD006655. DOI: 10.1002/14651858.CD006655.
- Amant F, Moerman P, Timmerman D, Limbergen EV, Vergote I. Endometrial cancer. Lancet 2005; 366: 491-505.
- Noone AM, Howlader N, Krapcho M, Miller D, Brest A, Yu M, Ruhl J, Tatalovich Z, Mariotto A, Lewis DR, Chen HS, Feuer EJ, Cronin KA (eds). SEER Cancer Statistics Review, 1975-2015, National Cancer Institute.
- Alektiar KM, McKee A, Lin O. Is there a difference in outcome between stage I-II endometrial cancer of papillary serous/clear cell and endometrioid FIGO grade 3 cancer? Int J Radiat Oncol Biol Phys. 2002; 54: 79–85.
- Cirisano FD, Robboy SJ, Dodge RK. Epidemiopathologic and surgicopathologic findings of papillary serous and clear cell endometrial cancers when compared to endometrioid carcinoma. Gynecol Oncol. 1999; 74: 385–94.
- Kosary CL. FIGO stage, histology, histologic grade, age and race as prognostic factors in determining survival for cancers of the female gynecological system: an analysis of 1973–1987 SEER cases of cancers of the endometrium, cervix, ovary, vulva, and vagina. Semin Surg Oncol. 1994; 10: 31–46.
- Tejerizo-García A, Jiménez-López JS, Muñoz-González JL, Bartolomé-Sotillos S, Marqueta-Marqués L, López-González G, Gómez JF. Overall survival and disease-free survival in endometrial cancer: prognostic factors in 276 patients. Onco Targets Ther. 2013; 9: 1305-13.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Ek |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Aralık 2019 |
| Gönderilme Tarihi | 15 Şubat 2019 |
| Yayımlandığı Sayı | Yıl 2019 |
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Bandırma Onyedi Eylül Üniversitesi Sağlık Bilimleri ve Araştırmaları Dergisi
https://doi.org/10.46413/boneyusbad.1076191