Yıl 2018, Cilt 57 , Sayı 1, Sayfalar 1 - 7 2018-03-01

Investigation of the factors influencing primary hypertension in childhood
Çocukluk çağı primer hipertansiyonuna etki eden faktörlerin araştırılması

İlknur GİRİŞGEN [1] , Ferah SÖNMEZ [2]


Aim: Primary hypertension is the most important risk factor for chronic kidney disease in adulthood. The genesis of essential hypertension is likely to be multifactorial. The aim of this study is to investigate the causing factors of primary hypertension detected by ambulatory blood pressure monitoring in children.

Materials and Methods: Fifty-six patients who had blood pressure higher than 90 percentile during the healthy children follow-up and 27 healthy children with the normal blood pressure were included in the study. Twenty-four hour blood pressure measurements with the blood pressure monitor were recorded as the day-night mean blood pressure, the blood pressure loads and the dipper-non-dipper characteristics. Plasma renin levels, serum aldosterone, nitric oxide and endothelin levels and amounts of sodium and potassium excretion in the 24 hour urine and were investigated in all patients and the control group.

Results: Laboratory evaluations of the patients showed that the patient group has higher mean levels of plasma renin, lower mean levels of blood endothelin and mean levels of urinary sodium excretion than the control group.

Conclusion: In the pathogenesis of childhood primary hypertension and white coat hypertension, which were seen in the half of the children diagnosed as primary hypertension, plasma renin and urinary sodium excretion had important roles.

Amaç: Primer hipertansiyon erişkin çağındaki kronik böbrek yetmezliği için başlıca risk faktörlerinden biridir. Esansiyel hipertansiyon sebepleri multifaktoriyeldir. Amacımız ambulatuar kan basıncı monitorizasyonu yapılmış primer hipertansiyon saptanan çocuklarda etyolojik faktörleri araştırmaktır.

Gereç ve Yöntem: Çalışmaya rutin sağlıklı çocuk kontrollerinde kan basınçları 90 persentilin üzerinde saptanan 56 çocuk ve kan basıncı 90 persentilin altında olan 27 sağlıklı çocuk alındı. Yirmi dört saatlik yaşam içi kan basıncı monitorizasyonu yapılarak gece gündüz kan basıncı ortalamaları, kan basıncı yükleri, dipper-non dipper özellikleri kaydedildi. Plazma renin aktivitesi, serum aldosteron, nitrik oksit, endotelin seviyeleri 24 saatlik idrarda sodyum ve potasyum atılımları karşılaştırıldı.

Bulgular: Laboratuvar değerlendirmelerinde hasta grupta kontrol gruba göre plazma renin aktivitesi yüksek, endotelin seviyesi düşük ve idrar sodyum atılımı yüksek saptandı.

Sonuç: Çocukluk çağı primer hipertansiyonu ve beyaz önlük hipertansiyonunda plazma renin düzeyinin ve idrar sodyum atılımının önemli rol oynadığı sonucuna varılmıştır.

Anahtar Sözcükler: Primer hipertansiyon, endotelin, renin
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Birincil Dil en
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Araştırma Makaleleri
Yazarlar

Orcid: 0000-0003-2617-4466
Yazar: İlknur GİRİŞGEN (Sorumlu Yazar)
Kurum: Adnan Menderes University Faculty of Medicine, Department of Pediatric Nephrology, Aydın
Ülke: Turkey


Orcid: 0000-0003-3027-5032
Yazar: Ferah SÖNMEZ
Kurum: ADNAN MENDERES ÜNİVERSİTESİ, TIP FAKÜLTESİ, CERRAHİ TIP BİLİMLERİ BÖLÜMÜ, ÜROLOJİ ANABİLİM DALI, ÇOCUK ÜROLOJİSİ BİLİM DALI
Ülke: Turkey


Tarihler

Başvuru Tarihi : 29 Eylül 2016
Kabul Tarihi : 20 Ocak 2017
Yayımlanma Tarihi : 1 Mart 2018

Bibtex @araştırma makalesi { etd414341, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege Üniversitesi}, year = {2018}, volume = {57}, pages = {1 - 7}, doi = {10.19161/etd.414341}, title = {Investigation of the factors influencing primary hypertension in childhood}, key = {cite}, author = {Gi̇ri̇şgen, İlknur and Sönmez, Ferah} }
APA Gi̇ri̇şgen, İ , Sönmez, F . (2018). Investigation of the factors influencing primary hypertension in childhood . Ege Tıp Dergisi , 57 (1) , 1-7 . DOI: 10.19161/etd.414341
MLA Gi̇ri̇şgen, İ , Sönmez, F . "Investigation of the factors influencing primary hypertension in childhood" . Ege Tıp Dergisi 57 (2018 ): 1-7 <http://egetipdergisi.com.tr/tr/pub/issue/36515/414341>
Chicago Gi̇ri̇şgen, İ , Sönmez, F . "Investigation of the factors influencing primary hypertension in childhood". Ege Tıp Dergisi 57 (2018 ): 1-7
RIS TY - JOUR T1 - Investigation of the factors influencing primary hypertension in childhood AU - İlknur Gi̇ri̇şgen , Ferah Sönmez Y1 - 2018 PY - 2018 N1 - doi: 10.19161/etd.414341 DO - 10.19161/etd.414341 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 1 EP - 7 VL - 57 IS - 1 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.414341 UR - https://doi.org/10.19161/etd.414341 Y2 - 2017 ER -
EndNote %0 Ege Tıp Dergisi Investigation of the factors influencing primary hypertension in childhood %A İlknur Gi̇ri̇şgen , Ferah Sönmez %T Investigation of the factors influencing primary hypertension in childhood %D 2018 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 57 %N 1 %R doi: 10.19161/etd.414341 %U 10.19161/etd.414341
ISNAD Gi̇ri̇şgen, İlknur , Sönmez, Ferah . "Investigation of the factors influencing primary hypertension in childhood". Ege Tıp Dergisi 57 / 1 (Mart 2018): 1-7 . https://doi.org/10.19161/etd.414341
AMA Gi̇ri̇şgen İ , Sönmez F . Investigation of the factors influencing primary hypertension in childhood. ETD. 2018; 57(1): 1-7.
Vancouver Gi̇ri̇şgen İ , Sönmez F . Investigation of the factors influencing primary hypertension in childhood. Ege Tıp Dergisi. 2018; 57(1): 1-7.
IEEE İ. Gi̇ri̇şgen ve F. Sönmez , "Investigation of the factors influencing primary hypertension in childhood", Ege Tıp Dergisi, c. 57, sayı. 1, ss. 1-7, Mar. 2018, doi:10.19161/etd.414341