Gelişme geriliği nedeni ile başvuran çocuklarda insulin benzeri büyüme faktörü-1 ile kalsiyum, fosfor ve Vitamin D düzeyleri arasındaki ilişkinin değerlendirilmesi

Eren Er; Didem Gülcü Taşkın

doi:10.19161/etd.1199175

EN TR

Evaluation of the relationship between ınsulin-like growth factor-1 and calcium, phosphorus and Vitamin D levels in children presenting with growth retardation

Abstract

Introduction-Aim: The main hormone that plays a role in growth at all stages of development is growth hormone (GH) and its mediator, insulin-like growth factor 1 (IGF-1). No scientific studies have yet clarified the relationship between IGF-1 and calcium, phosphorus and vitamin D. The aim of this study is to investigate the effect of serum calcium, phosphorus and vitamin D levels on insulin-like growth factor 1 (IGF-1) in children who are admitted with growth retardation. Materials-Methods: 155 children (80 male, 75 female) admitted to Adana City Training and Research Hospital Pediatric Gastroenterology Outpatient Clinic 1 between 01.10.2017-31.08.2022 due to growth retardation were included in this retrospective study. Anthropometric and biochemical data files were obtained. The relationship between serum calcium, phosphorus and vitamin D and IGF-1 was analyzed. Results: The mean age of the children participating in the study was 8.13 ± 4.98 years. The mean IGF-1 level of the participants was 115.06 ± 83.33 ng/ml. Mean serum calcium, phosphorus and 25(OH)D levels were 9.79 ± 0.43 mg/dl, 4.76 ± 0.59 mg/dl and 31.49 ± 12.9 ng/ml, respectively. Univariate analysis results showed that serum phosphorus was significantly correlated with IGF-1 level. In addition, a linear relationship was observed between serum phosphorus and IGF-1 level, after adjusting for possible confounding factors. According to the results of the adjusted linear regression, no significant correlation could be demonstrated with serum calcium and 25(OH)D level and IGF-1 level (respectively, β: 0.045, 95% CI: -11.583; 28.863, p =0.400 and β: -0.018, respectively; 95% CI: -0.845;0.617, p = 0.758 ). However, serum phosphorus has been shown to be positively associated with IGF-1 (β: 0.122, 95% CI: 1.31;33.16; p = 0.034). Conclusion: This study showed that serum phosphorus levels may be significantly related to IGF-1 levels in children who presented with growth retardation. Additional research is needed to fully elucidate the relationship between serum calcium, phosphorus, and vitamin D and IGF-1.

Keywords

Gelişme geriliği nedeni ile başvuran çocuklarda insulin benzeri büyüme faktörü-1 ile kalsiyum, fosfor ve Vitamin D düzeyleri arasındaki ilişkinin değerlendirilmesi

Öz

Giriş-Amaç: Gelişimin tüm aşamalarında büyümede rol oynayan ana hormon, büyüme hormonu (BH) ve onun aracısı olan insülin benzeri büyüme faktörü 1'dir (IGF-1). IGF-1 ile kalsiyum, fosfor ve D vitamini arasındaki ilişki henüz hiçbir bilimsel çalışma netleştirmemiştir. Bu çalışmanın amacı, gelişme geriliği nedeni ile başvuran çocuklarda serum kalsiyum, fosfor ve D vitamini düzeylerinin insülin benzeri büyüme faktörü 1 (IGF-1) üzerindeki etkisini araştırmaktır. Gereç-Yöntem: Bu retrospektif çalışmaya, Adana Şehir Eğitim ve Araştırma Hastanesi Çocuk Gastroenteroloji Poliklinik 1’de 01.10.2017-31.08.2022 tarihleri arasında gelişme geriliği nedeni ile başvuran 155 (80 kız, 75 erkek) çocuk dahil edildi. Antropometrik ve laboratuvar verileri hasta dosyalarından elde edildi. Serum kalsiyum, fosfor ve D vitamini ile IGF-1 arasındaki ilişki analiz edildi. Bulgular: Çalışmaya katılan çocukların ortalama yaşı 8,13 ± 4,98 yıl idi. Katılımcıların ortalama IGF-1 düzeyi 115,06 ± 83,33 ng/ml idi. Ortalama serum kalsiyum, fosfor ve 25(OH)D seviyeleri sırasıyla 9,79 ± 0,43 mg/dl, 4,76 ± 0,59 mg/dl ve 31,49 ± 12,9 ng/ml idi. Tek değişkenli analiz sonuçları, serum fosforunun, IGF-1 düzeyi ile anlamlı derecede ilişkili olduğunu gösterdi. Ek olarak, olası karıştırıcı faktörler için düzeltildikten sonra, serum fosforu ile IGF-1 düzeyi arasında doğrusal bir ilişki gözlemlendi. Düzeltilmiş lineer regresyonun sonuçlarına göre, serum kalsiyumu ve 25(OH)D düzeyi ile IGF-1 düzeyi ile anlamlı bir ilişkili gösterilemedi (sırasıyla, β: 0,045, %95 CI: -11,583;28,863, p =0,400 ve β: -0,018, %95 CI: -0,845;0,617, p = 0,758 ). Ancak serum fosforun IGF-1 ile pozitif olarak ilişkili olduğunu gösterilmiştir (β: 0,122, %95 CI: 1,31;33,16; p = 0.034). Sonuç: Bu çalışma, gelişme geriliği nedeni ile başvuran çocuklarda serum fosfor düzeylerini IGF-1 düzeyleri ile anlamlı ilişkili olabileceğini göstermiştir. Serum kalsiyum, fosfor ve D vitamini ile IGF-1 arasındaki ilişkiyi tam olarak aydınlatmak için ek araştırmalara ihtiyaç vardır.

Anahtar Kelimeler

References

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Details

Primary Language

Turkish

Subjects

Pediatric Endocrinology , Pediatric Gastroenterology

Journal Section

Research Article

Authors

Eren Er ^*
0000-0003-4770-0365
Türkiye

Didem Gülcü Taşkın
0000-0002-2746-3799
Türkiye

Publication Date

September 18, 2023

Submission Date

November 3, 2022

Acceptance Date

February 1, 2023

Published in Issue

Year 2023 Volume: 62 Number: 3

DOI

https://doi.org/10.19161/etd.1199175

IZ

https://izlik.org/JA48RR85MH

Cite

RIS / Bibtex

Vancouver

1.Eren Er, Didem Gülcü Taşkın. Gelişme geriliği nedeni ile başvuran çocuklarda insulin benzeri büyüme faktörü-1 ile kalsiyum, fosfor ve Vitamin D düzeyleri arasındaki ilişkinin değerlendirilmesi. EJM. 2023 Sep. 1;62(3):467-72. doi:10.19161/etd.1199175