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Evaluation of the relationship between ınsulin-like growth factor-1 and calcium, phosphorus and Vitamin D levels in children presenting with growth retardation
Abstract
Introduction-Aim: The main hormone that plays a role in growth at all stages of development is growth hormone (GH) and its mediator, insulin-like growth factor 1 (IGF-1). No scientific studies have yet clarified the relationship between IGF-1 and calcium, phosphorus and vitamin D. The aim of this study is to investigate the effect of serum calcium, phosphorus and vitamin D levels on insulin-like growth factor 1 (IGF-1) in children who are admitted with growth retardation.
Materials-Methods: 155 children (80 male, 75 female) admitted to Adana City Training and Research Hospital Pediatric Gastroenterology Outpatient Clinic 1 between 01.10.2017-31.08.2022 due to growth retardation were included in this retrospective study. Anthropometric and biochemical data files were obtained. The relationship between serum calcium, phosphorus and vitamin D and IGF-1 was analyzed.
Results: The mean age of the children participating in the study was 8.13 ± 4.98 years. The mean IGF-1 level of the participants was 115.06 ± 83.33 ng/ml. Mean serum calcium, phosphorus and 25(OH)D levels were 9.79 ± 0.43 mg/dl, 4.76 ± 0.59 mg/dl and 31.49 ± 12.9 ng/ml, respectively. Univariate analysis results showed that serum phosphorus was significantly correlated with IGF-1 level. In addition, a linear relationship was observed between serum phosphorus and IGF-1 level, after adjusting for possible confounding factors. According to the results of the adjusted linear regression, no significant correlation could be demonstrated with serum calcium and 25(OH)D level and IGF-1 level (respectively, β: 0.045, 95% CI: -11.583; 28.863, p =0.400 and β: -0.018, respectively; 95% CI: -0.845;0.617, p = 0.758 ). However, serum phosphorus has been shown to be positively associated with IGF-1 (β: 0.122, 95% CI: 1.31;33.16; p = 0.034).
Conclusion: This study showed that serum phosphorus levels may be significantly related to IGF-1 levels in children who presented with growth retardation. Additional research is needed to fully elucidate the relationship between serum calcium, phosphorus, and vitamin D and IGF-1.
Keywords
Kaynakça
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Ayrıntılar
Birincil Dil
Türkçe
Konular
Çocuk Endokrinolojisi , Çocuk Gastroenterolojisi
Bölüm
Araştırma Makalesi
Yayımlanma Tarihi
18 Eylül 2023
Gönderilme Tarihi
3 Kasım 2022
Kabul Tarihi
1 Şubat 2023
Yayımlandığı Sayı
Yıl 1970 Cilt: 62 Sayı: 3