Review

The subtleties of insulin treatment in patients with lipodystrophy

Volume: 62 Number: 1 March 15, 2023
  • Ilgin Yildirim Simsir *
  • Utku Erdem Soyaltin
  • Sevki Cetinkalp
  • Baris Akinci
TR EN

The subtleties of insulin treatment in patients with lipodystrophy

Abstract

In the treatment of Diabetes Mellitus (DM), which develops on the basis of insulin resistance in patients with lipodystrophy (LD) often require high doses of insulin. Traditionally in practice is to gradually increase the insulin doses to achieve blood glucose normalization. The fact that high insulin doses require a larger injection volume, which causes impairment in the absorption of insulin from the subcutaneous tissue to the circulation. In this article, we discussed the clinical approach to insulin practice in the treatment of DM in patients with LD and reviewed systematically the literature.

Keywords

References

  1. Oral EA. Lipoatrophic diabetes and other related syndromes. Rev Endocr Metab Disord. 2003; 4 (1): 61-77. https://doi.org/10.1023/a:1021827520301.
  2. Chan JL, Oral EA. Clinical classification and treatment of congenital and acquired lipodystrophy. Endocr Pract. 2010; 16 (2): 310-23. https://doi.org/10.4158/EP09154.RA.
  3. Akinci B, Sahinoz M, Oral A, et al. Lipodystrophy Syndromes: Presentation and Treatment. In: Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-2018 Apr 24. PMID: 29989768. https://www.ncbi.nlm.nih.gov/books/NBK513130/
  4. Ferrara D, Montecucco F, Dallegri F, et al. Impact of different ectopic fat depots on cardiovascular and metabolic diseases. J Cell Physiol. 2019; 234 (12): 21630-41. https://doi.org/10.1002/jcp.28821.
  5. Binder C. Absorption of injected insulin. A clinicalpharmacological study. Acta Pharmacol Toxicol (Copenh). 1969; 27 (Suppl. 2): 1-84. https://doi.org/10.1111/j.1600-0773.1969.tb03069.x.
  6. Gradel AKJ, Porsgaard T, Lykkesfeldt J, et al. Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability. J Diabetes Res. 2018; 2018: 1205121. https://doi.org/10.1155/2018/1205121.
  7. Vantyghem MC, Vigouroux C, Magre J, et al. Late-onset lipoatrophic diabetes. Phenotypic and genotypic familial studies and effect of treatment with metformin and lispro insulin analog. Diabetes Care. 1999; 22 (8):1374-6. https://doi.org/10.2337/diacare.22.8.1374.
  8. Moreau F, Boullu-Sanchis S, Vigouroux C, et al. Efficacy of pioglitazone in familial partial lipodystrophy of the Dunnigan type: a case report. Diabetes Metab. 2007;33(5):385-9. https://doi.org/10.1016/j.diabet.2007.04.005.

Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Review

Authors

Ilgin Yildirim Simsir *
Türkiye

Utku Erdem Soyaltin
Türkiye

Sevki Cetinkalp
Türkiye

Baris Akinci
Türkiye

Publication Date

March 15, 2023

Submission Date

March 3, 2022

Acceptance Date

December 7, 2022

Published in Issue

Year 2023 Volume: 62 Number: 1

Vancouver
1.Ilgin Yildirim Simsir, Utku Erdem Soyaltin, Sevki Cetinkalp, Baris Akinci. The subtleties of insulin treatment in patients with lipodystrophy. EJM. 2023 Mar. 1;62(1):158-62. doi:10.19161/etd.1262624

Ege Journal of Medicine enables the sharing of articles according to the Attribution-Non-Commercial-Share Alike 4.0 International (CC BY-NC-SA 4.0) license.