Derleme

The subtleties of insulin treatment in patients with lipodystrophy

Cilt: 62 Sayı: 1 15 Mart 2023
  • Ilgin Yildirim Simsir *
  • Utku Erdem Soyaltin
  • Sevki Cetinkalp
  • Baris Akinci
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The subtleties of insulin treatment in patients with lipodystrophy

Öz

In the treatment of Diabetes Mellitus (DM), which develops on the basis of insulin resistance in patients with lipodystrophy (LD) often require high doses of insulin. Traditionally in practice is to gradually increase the insulin doses to achieve blood glucose normalization. The fact that high insulin doses require a larger injection volume, which causes impairment in the absorption of insulin from the subcutaneous tissue to the circulation. In this article, we discussed the clinical approach to insulin practice in the treatment of DM in patients with LD and reviewed systematically the literature.

Anahtar Kelimeler

Kaynakça

  1. Oral EA. Lipoatrophic diabetes and other related syndromes. Rev Endocr Metab Disord. 2003; 4 (1): 61-77. https://doi.org/10.1023/a:1021827520301.
  2. Chan JL, Oral EA. Clinical classification and treatment of congenital and acquired lipodystrophy. Endocr Pract. 2010; 16 (2): 310-23. https://doi.org/10.4158/EP09154.RA.
  3. Akinci B, Sahinoz M, Oral A, et al. Lipodystrophy Syndromes: Presentation and Treatment. In: Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000-2018 Apr 24. PMID: 29989768. https://www.ncbi.nlm.nih.gov/books/NBK513130/
  4. Ferrara D, Montecucco F, Dallegri F, et al. Impact of different ectopic fat depots on cardiovascular and metabolic diseases. J Cell Physiol. 2019; 234 (12): 21630-41. https://doi.org/10.1002/jcp.28821.
  5. Binder C. Absorption of injected insulin. A clinicalpharmacological study. Acta Pharmacol Toxicol (Copenh). 1969; 27 (Suppl. 2): 1-84. https://doi.org/10.1111/j.1600-0773.1969.tb03069.x.
  6. Gradel AKJ, Porsgaard T, Lykkesfeldt J, et al. Factors Affecting the Absorption of Subcutaneously Administered Insulin: Effect on Variability. J Diabetes Res. 2018; 2018: 1205121. https://doi.org/10.1155/2018/1205121.
  7. Vantyghem MC, Vigouroux C, Magre J, et al. Late-onset lipoatrophic diabetes. Phenotypic and genotypic familial studies and effect of treatment with metformin and lispro insulin analog. Diabetes Care. 1999; 22 (8):1374-6. https://doi.org/10.2337/diacare.22.8.1374.
  8. Moreau F, Boullu-Sanchis S, Vigouroux C, et al. Efficacy of pioglitazone in familial partial lipodystrophy of the Dunnigan type: a case report. Diabetes Metab. 2007;33(5):385-9. https://doi.org/10.1016/j.diabet.2007.04.005.

Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Derleme

Yazarlar

Ilgin Yildirim Simsir *
Türkiye

Utku Erdem Soyaltin
Türkiye

Sevki Cetinkalp
Türkiye

Baris Akinci
Türkiye

Yayımlanma Tarihi

15 Mart 2023

Gönderilme Tarihi

3 Mart 2022

Kabul Tarihi

7 Aralık 2022

Yayımlandığı Sayı

Yıl 2023 Cilt: 62 Sayı: 1

Kaynak Göster

APA
Yildirim Simsir, I., Soyaltin, U. E., Cetinkalp, S., & Akinci, B. (2023). The subtleties of insulin treatment in patients with lipodystrophy. Ege Tıp Dergisi, 62(1), 158-162. https://doi.org/10.19161/etd.1262624
AMA
1.Yildirim Simsir I, Soyaltin UE, Cetinkalp S, Akinci B. The subtleties of insulin treatment in patients with lipodystrophy. ETD. 2023;62(1):158-162. doi:10.19161/etd.1262624
Chicago
Yildirim Simsir, Ilgin, Utku Erdem Soyaltin, Sevki Cetinkalp, ve Baris Akinci. 2023. “The subtleties of insulin treatment in patients with lipodystrophy”. Ege Tıp Dergisi 62 (1): 158-62. https://doi.org/10.19161/etd.1262624.
EndNote
Yildirim Simsir I, Soyaltin UE, Cetinkalp S, Akinci B (01 Mart 2023) The subtleties of insulin treatment in patients with lipodystrophy. Ege Tıp Dergisi 62 1 158–162.
IEEE
[1]I. Yildirim Simsir, U. E. Soyaltin, S. Cetinkalp, ve B. Akinci, “The subtleties of insulin treatment in patients with lipodystrophy”, ETD, c. 62, sy 1, ss. 158–162, Mar. 2023, doi: 10.19161/etd.1262624.
ISNAD
Yildirim Simsir, Ilgin - Soyaltin, Utku Erdem - Cetinkalp, Sevki - Akinci, Baris. “The subtleties of insulin treatment in patients with lipodystrophy”. Ege Tıp Dergisi 62/1 (01 Mart 2023): 158-162. https://doi.org/10.19161/etd.1262624.
JAMA
1.Yildirim Simsir I, Soyaltin UE, Cetinkalp S, Akinci B. The subtleties of insulin treatment in patients with lipodystrophy. ETD. 2023;62:158–162.
MLA
Yildirim Simsir, Ilgin, vd. “The subtleties of insulin treatment in patients with lipodystrophy”. Ege Tıp Dergisi, c. 62, sy 1, Mart 2023, ss. 158-62, doi:10.19161/etd.1262624.
Vancouver
1.Ilgin Yildirim Simsir, Utku Erdem Soyaltin, Sevki Cetinkalp, Baris Akinci. The subtleties of insulin treatment in patients with lipodystrophy. ETD. 01 Mart 2023;62(1):158-62. doi:10.19161/etd.1262624

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