Pediatric Cases Diagnosed with Drug-Related Acute Tubulointerstitial Nephritis: A Single-Center Experience

Özgür Özdemir Şimşek; Gökçen Erfidan; Caner Alparslan; Cemaliye Başaran; Seçil Arslansoyu Çamlar; Fatma Mutlubaş; Belde Kasap Demir; Demet Alaygut

doi:10.19161/etd.1301127

EN TR

Pediatric Cases Diagnosed with Drug-Related Acute Tubulointerstitial Nephritis: A Single-Center Experience

Abstract

Aim: Acute tubulointerstitial nephritis (TIN) is inflammation of the renal interstitium. It is also a common cause of acute kidney injury (AKI). The aim is to contribute to the literature by evaluating patients diagnosed with drug-induced TIN. Material methods: 29 Turkish children aged between 3 and 217 months, 5 of whom had undergone a biopsy, were retrospectively analyzed in terms of clinical and laboratory findings. Results: 29 patients, 19 of whom were girls, were evaluated. The mean age at diagnosis was 138.6(3-217) ± 67.4 months. Nausea-vomiting complaint of 12 cases, 6 under treatment during hospitalization, 4 with headache, 2 with isolated fatigue, and the remaining 5 patients with incidentally detected renal function test disorder, oligo-anuria, urinary incontinence, red urination, and uveitis. At the time of diagnosis, 4 patients had hypertension and 26 patients had AKI. Two of these cases were anuric. The low eGFR values at the time of diagnosis were observed to improve at the end of the follow-up. Hematuria was detected in 18 cases and of them were macroscopic hematuria. 4 patients had pyuria, 19 patients had proteinuria, and 2 of them were nephrotic. FeNa was the most common abnormality of the tubular tests with 4.5%. Biopsy was performed in 5 cases. While one of the patients presented with uveitis, uveitis developed in 1 patient during the 3rd month of follow-up. Conclusion: Consequently, although TIN is a reversible disease, its recognition is important in terms of treatment and follow-up.

Keywords

Çocuk Hastalarda İlaç İlişkili Akut Tübülointerstisyel Nefritin Değerlendirilmesi: Tek Merkez Deneyimi

Öz

Amaç: Akut tubulointerstisyel nefrit (TIN), renal interstisyumun inflamasyonudur. Aynı zamanda akut böbrek hasarının (ABH) yaygın bir nedenidir. Amaç ilaca bağlı TIN tanısı alan hastaları değerlendirerek literatüre katkıda bulunmaktır. Gereç ve Yöntem: Yaşları 3-217 ay olan 29 Türk çocuğu klinik ve laboratuvar bulguları açısından retrospektif olarak incelendi. 5 hastaya biyopsi yapıldığı görüldü. Bulgular: 19'u kız olmak üzere 29 hasta değerlendirildi. Ortalama tanı yaşı 138,6(3-217) ± 67,4 ay idi. Başvuru şikayetleri değerlendirildiğinde 12 hastada bulantı-kusma, 4 hastada başağrısı ve 2 hastada izole halsizlik olduğu görüldü. 5 hastanın başka sebeplerle hastaneye başvurusu sonucu insidental olarak, 6 ise hastanın farklı nedenlerle hospitalizasyonu sırasında izlemde tanı aldığı belirlendi. 26 hastada ABH bulunmaktaydı ve 4 hasta hipertansifti. İki hasta anürikti. Tanı anında düşük olan eGFR değerlerinin takip sonunda düzeldiği görüldü. 18 olguda hematüri saptandı ve makroskopikti. 4 hastada piyüri, 19 hastada proteinüri vardı ve 2 hastada nefrotik düzeydeydi. FeNa %4,5 ile tübüler testlerde en sık görülen anormallikti. 5 olguya biyopsi yapıldı. Hastalardan biri üveit şikayeti ile başvururken, 1 hastanın takibinin 3. ayında üveit gelişti. Sonuç: Sonuç olarak TIN geri dönüşümlü bir hastalık olmasına rağmen tanınması tedavi ve takip açısından önemlidir.

Anahtar Kelimeler

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Özgür Özdemir Şimşek ^*
0000-0001-5705-7452
Türkiye

Gökçen Erfidan
0000-0001-5217-5847
Türkiye

Caner Alparslan
0000-0002-7046-8907
Türkiye

Cemaliye Başaran
0000-0002-6422-7998
Türkiye

Seçil Arslansoyu Çamlar
0000-0002-2402-0722
Türkiye

Fatma Mutlubaş
0000-0001-9392-4832
Türkiye

Belde Kasap Demir
0000-0002-5456-3509
Türkiye

Demet Alaygut
0000-0002-2164-4652
Türkiye

Publication Date

March 19, 2024

Submission Date

May 23, 2023

Acceptance Date

August 10, 2023

Published in Issue

Year 2024 Volume: 63 Number: 1

DOI

https://doi.org/10.19161/etd.1301127

IZ

https://izlik.org/JA92GK22BF

Cite

RIS / Bibtex

Vancouver

1.Özgür Özdemir Şimşek, Gökçen Erfidan, Caner Alparslan, Cemaliye Başaran, Seçil Arslansoyu Çamlar, Fatma Mutlubaş, Belde Kasap Demir, Demet Alaygut. Pediatric Cases Diagnosed with Drug-Related Acute Tubulointerstitial Nephritis: A Single-Center Experience. EJM. 2024 Mar. 1;63(1):78-85. doi:10.19161/etd.1301127