Araştırma Makalesi

Pediatric Cases Diagnosed with Drug-Related Acute Tubulointerstitial Nephritis: A Single-Center Experience

Cilt: 63 Sayı: 1 19 Mart 2024
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Pediatric Cases Diagnosed with Drug-Related Acute Tubulointerstitial Nephritis: A Single-Center Experience

Abstract

Aim: Acute tubulointerstitial nephritis (TIN) is inflammation of the renal interstitium. It is also a common cause of acute kidney injury (AKI). The aim is to contribute to the literature by evaluating patients diagnosed with drug-induced TIN. Material methods: 29 Turkish children aged between 3 and 217 months, 5 of whom had undergone a biopsy, were retrospectively analyzed in terms of clinical and laboratory findings. Results: 29 patients, 19 of whom were girls, were evaluated. The mean age at diagnosis was 138.6(3-217) ± 67.4 months. Nausea-vomiting complaint of 12 cases, 6 under treatment during hospitalization, 4 with headache, 2 with isolated fatigue, and the remaining 5 patients with incidentally detected renal function test disorder, oligo-anuria, urinary incontinence, red urination, and uveitis. At the time of diagnosis, 4 patients had hypertension and 26 patients had AKI. Two of these cases were anuric. The low eGFR values at the time of diagnosis were observed to improve at the end of the follow-up. Hematuria was detected in 18 cases and of them were macroscopic hematuria. 4 patients had pyuria, 19 patients had proteinuria, and 2 of them were nephrotic. FeNa was the most common abnormality of the tubular tests with 4.5%. Biopsy was performed in 5 cases. While one of the patients presented with uveitis, uveitis developed in 1 patient during the 3rd month of follow-up. Conclusion: Consequently, although TIN is a reversible disease, its recognition is important in terms of treatment and follow-up.

Keywords

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Yayımlanma Tarihi

19 Mart 2024

Gönderilme Tarihi

23 Mayıs 2023

Kabul Tarihi

10 Ağustos 2023

Yayımlandığı Sayı

Yıl 2024 Cilt: 63 Sayı: 1

DOI

https://doi.org/10.19161/etd.1301127

IZ

https://izlik.org/JA92GK22BF

Kaynak Göster

RIS / Bibtex
Vancouver
1.Özgür Özdemir Şimşek, Gökçen Erfidan, Caner Alparslan, Cemaliye Başaran, Seçil Arslansoyu Çamlar, Fatma Mutlubaş, Belde Kasap Demir, Demet Alaygut. Pediatric Cases Diagnosed with Drug-Related Acute Tubulointerstitial Nephritis: A Single-Center Experience. ETD. 01 Mart 2024;63(1):78-85. doi:10.19161/etd.1301127

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