Two fighters against oxidative stress in peripheral organs in Parkinson's Disease: Brain-derived neurotrophic factor and hydrogen sulfide

Berna Tezcan Yavuz; Cansın Şirin; Canberk Tomruk; Gulay Hacıoğlu; Selma Cırrık; Emine Gülçeri Güleç Peker; Selçuk Takır

doi:10.19161/etd.1355434

TR EN

Parkinson hastalığında periferik organlardaki oksidatif strese karşı iki savaşçı: Beyin kaynaklı nörotrofik faktör ve hidrojen sülfit

Öz

Amaç: Nörodejeneratif bir hastalık olan Parkinson hastalığının beyinde olduğu gibi periferik organlarda da olumsuz sonuçları vardır. Bu çalışmada farelerde oluşturulan Parkinson hastalığı modelinde beyin kaynaklı nörotrofik faktör ve hidrojen sülfitin karaciğer, böbrek, mide ve bağırsak üzerindeki etkilerinin araştırılması amaçlanmaktadır. Gereç ve Yöntem: Parkinson hastalığı modelinin başarısını ve beyin kaynaklı nörotrofik faktör ile hidrojen sülfitin bu model üzerindeki etkilerini değerlendirmek için tüm gruplardaki hayvanlar motor davranış testlerine tabi tutuldu. Periferik organlardaki oksidatif stres, biyokimyasal olarak toplam oksidan ve toplam antioksidan seviyeleri ölçülerek belirlendi. Ayrıca histolojik olarak doku hasarı ve hücresel dejenerasyon bakımından değerlendirildi. Bulgular: Motor davranış testlerine göre hidrojen sülfitin Parkinson hastalığına karşı motor performansı ve koordinasyonu arttırdığı, bradikineziyi azalttığı ortaya çıktı. Deneysel Parkinson hastalığı ve beyin kaynaklı nörotrofik faktörün inhibisyonu, karaciğer, böbrek ve bağırsakta oksidatif stresin neden olduğu dejenerasyona işaret eden hücresel değişikliklere neden oldu. Hidrojen sülfitin özellikle karaciğer ve bağırsak dokusunda histolojik yapıyı koruduğu ve karaciğerde antioksidan kapasiteyi artırarak, bağırsakta ise oksidan kapasiteyi azaltarak süreci desteklediği ortaya çıktı. Sonuç: Beyin kaynaklı nörotrofik faktör ve hidrojen sülfitin, Parkinson hastalığına bağlı olarak periferik organlarda meydana gelen oksidatif stres üzerinde, farklı ancak genel olarak koruyucu etkileri vardır.

Anahtar Kelimeler

Two fighters against oxidative stress in peripheral organs in Parkinson's Disease: Brain-derived neurotrophic factor and hydrogen sulfide

Abstract

Aim: Parkinson's disease, which is a neurodegenerative disorder, has adverse consequences on peripheral organs as well as the brain. This study aims to investigate the effects of brain-derived neurotrophic factor and hydrogen sulfide on liver, kidney, stomach and intestine in Parkinson's disease model created in mice. Materials and Methods: To assess the achievement of the Parkinson's disease model and the effects of brain-derived neurotrophic factor and hydrogen sulfide on this model, animals in all groups were subjected to motor behavior tests. Oxidative stress in peripheral organs was determined biochemically by measuring total oxidant and total antioxidant levels. It was also evaluated histologically in terms of tissue damage and cellular degeneration. Results: According to the motor behaviour tests it was revealed that hydrogen sulfide increased motor performance and coordination against Parkinson's disease and decreased bradykinesia. Experimental Parkinson's Disease and inhibition of the brain-derived neurotrophic factor caused cellular changes in the liver, kidney, and intestine indicating oxidative stress-induced degeneration. It was revealed that hydrogen sulfide protects the histological structure especially in the liver and intestinal tissue and supports the process by increasing the antioxidant capacity in the liver and decreasing the oxidant capacity in the intestine. Conclusion: Brain-derived neurotrophic factor and hydrogen sulfide have different but generaly protective effects on oxidative stress in peripheral organs due to Parkinson's disease.

Keywords

Ethical Statement

The authors declare no conflict of interest.

Thanks

The authors would like to thank Prof. Dr. Yigit UYANIKGIL, faculty member of Ege University Faculty of Medicine, Department of Histology and Embryology, for all his scientific support.

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Details

Primary Language

English

Subjects

Central Nervous System , Histology and Embryology

Journal Section

Research Article

Authors

Berna Tezcan Yavuz ^*
0000-0002-7410-9485
Türkiye

Cansın Şirin
0000-0002-4530-701X
Türkiye

Canberk Tomruk
0000-0002-3810-3705
Türkiye

Gulay Hacıoğlu
0000-0002-8528-2371
Türkiye

Selma Cırrık
0000-0001-8474-0185
Türkiye

Emine Gülçeri Güleç Peker
0000-0001-7244-0281
Türkiye

Selçuk Takır
0000-0002-9130-9518
Türkiye

Publication Date

June 10, 2024

Submission Date

September 5, 2023

Acceptance Date

October 17, 2023

Published in Issue

Year 2024 Volume: 63 Number: 2

DOI

https://doi.org/10.19161/etd.1355434

IZ

https://izlik.org/JA46RT42LG

Cite

RIS / Bibtex

Vancouver

1.Berna Tezcan Yavuz, Cansın Şirin, Canberk Tomruk, Gulay Hacıoğlu, Selma Cırrık, Emine Gülçeri Güleç Peker, Selçuk Takır. Two fighters against oxidative stress in peripheral organs in Parkinson’s Disease: Brain-derived neurotrophic factor and hydrogen sulfide. EJM. 2024 Jun. 1;63(2):206-14. doi:10.19161/etd.1355434

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