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Single-center and reverse evaluation of febrile neutropenic attacks of patients followed with acute myeloid leukemia diagnosis
Abstract
Aim: Since fever may be the only symptom in patients with hematological malignancy, fever in neutropenic patients is considered to be related to infection until proven otherwise. The standard approach is the rapid evaluation of febrile neutropenic (FEN) episodes and initiation of appropriate antibiotic treatment. In this study, it was aimed to examine the duration of FEN, infection categories, symptoms and examination findings, isolated microorganisms and mortality rates of the patients we followed up in our clinic due to acute myeloid leukemia.
Materials and Methods: We examined 155 adult patients with AML who were treated at the Adult Hematology Clinic. In our study, we retrospectively evaluated 337 chemotherapy-related FEN episodes in terms of infection categories, offending pathogenic microorganisms and mortality rates.
Results: 43.92% (n=148) of the patients had pathological examination findings accompanying the fever. FEN attacks in 249 patients had clinically and/or microbiologically proven foci of infection. The most frequent infection site was the lungs (41.5%). The most frequently isolated microorganisms were found to be coagulase negative staphylococcus (37.30%) and E.coli (36.21%). 32.94% of the patients (n=111) were recorded as smokers. When the relationship between smoking and lung infection was investigated, it was determined that the incidence of lung infection was higher in smokers (p= 0.007). In 91 (27%) of those who had a FEN attack in our hospital resulted in death. It was the lung infection that mostly correlated with the mortality (40.71%).
Conclusion: Each clinic can determine empirical antibiotic treatment policies by investigating infectious agents. It can manage the FEN episode process more accurately by providing the necessary infection control measures.
Keywords
Ethical Statement
This study was given ethical approval by the Ege University Faculty of Medicine Clinical Research ethics committee.
References
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Details
Primary Language
English
Subjects
Haematology , Internal Diseases
Journal Section
Research Article
Publication Date
March 12, 2025
Submission Date
March 25, 2024
Acceptance Date
December 19, 2024
Published in Issue
Year 2025 Volume: 64 Number: 1