Assessment of serum bisphenol a levels in autoimmune thyroiditis: A case-control study

Gokcen Ünal Kocabaş; Murat Akşit; Ilgın Yıldırım Şimşir; Füsun Saygılı; Banu Sarer Yürekli

doi:10.19161/etd.1544200

EN TR

Assessment of serum bisphenol a levels in autoimmune thyroiditis: A case-control study

Abstract

Aim: The precise mechanism underlying autoimmune thyroiditis is still unclear. The female preponderance suggests the role of estrogens in autoimmunity, and there is strong evidence about this role. Bisphenol A (BPA), a widely used endocrine disruptor, may have estrogenic effects and affect autoimmunity through estrogenic and non-estrogenic mechanisms. We aimed to determine the relationship between serum BPA levels and thyroid autoimmunity. Materials and Methods: We performed a cross-sectional case-control study involving 143 autoimmune thyroiditis patients and 95 age-matched healthy controls. Serum BPA levels were measured using ELISA method. Results: BPA levels were not significantly different between autoimmune thyroiditis and control groups. The percentage of antibody-positive patients, thyroid function, thyroid antibody levels, or BMI were not different between BPA quartiles. Also, there was no correlation between BPA levels and thyroid autoantibody levels. Conclusion: Serum BPA levels were not significantly different in autoimmune thyroiditis. Also, we could not show any relationship between BPA, thyroid function tests, and thyroid antibody levels.

Keywords

Otoimmün tiroidit’te Serum Bisfenol A düzeylerinin değerlendirilmesi: Bir vaka-kontrol çalışması

Öz

Amaç: Otoimmün tiroiditin altında yatan kesin mekanizma hala belirsizdir. Kadınların baskın olması, östrojenlerin otoimmünitedeki rolünü düşündürmektedir ve bu rol hakkında güçlü kanıtlar bulunmaktadır. Yaygın olarak kullanılan bir endokrin bozucu olan Bisfenol A (BPA), östrojenik etkilere sahip olabilir ve östrojenik ve östrojenik olmayan mekanizmalar aracılığıyla otoimmüniteyi etkileyebilir. Serum BPA düzeyleri ile tiroid otoimmünitesi arasındaki ilişkiyi belirlemeyi amaçladık. Gereç ve Yöntem: 143 otoimmün tiroidit hastası ve 95 yaş eşleştirilmiş sağlıklı kontrol içeren kesitsel bir olgu-kontrol çalışması gerçekleştirdik. Serum BPA düzeyleri ELISA yöntemi kullanılarak ölçüldü. Bulgular: BPA düzeyleri otoimmün tiroidit ve kontrol grupları arasında anlamlı ölçüde farklı değildi. Antikor pozitif hastaların yüzdesi, tiroid fonksiyonu, tiroid antikor düzeyleri veya BKİ açısından BPA dörtlükleri arasında fark saptanmadı. Ayrıca, BPA düzeyleri ile tiroid oto antikor düzeyleri arasında bir korelasyon yoktu. Sonuç: Serum BPA düzeyleri otoimmün tiroiditte önemli ölçüde farklı değildi. Ayrıca, BPA, tiroid fonksiyon testleri ve tiroid antikor düzeyleri arasında herhangi bir ilişki gösteremedik.

Anahtar Kelimeler

Supporting Institution

Ege Üniversitesi Bilimsel Araştırma Projeleri : 2014-TIP-029

Project Number

2014-TIP-029

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Details

Primary Language

English

Subjects

Endocrinology

Journal Section

Research Article

Authors

Gokcen Ünal Kocabaş ^*
0000-0002-1849-3179
Türkiye

Murat Akşit
0000-0003-2106-9130
Türkiye

Ilgın Yıldırım Şimşir
0000-0002-6801-8499
Türkiye

Füsun Saygılı
0000-0002-4451-6530
Türkiye

Banu Sarer Yürekli
0000-0003-1809-2655
Türkiye

Publication Date

March 12, 2025

Submission Date

September 5, 2024

Acceptance Date

October 5, 2024

Published in Issue

Year 2025 Volume: 64 Number: 1

DOI

https://doi.org/10.19161/etd.1544200

IZ

https://izlik.org/JA52GF82PR

Cite

RIS / Bibtex

Vancouver

1.Gokcen Ünal Kocabaş, Murat Akşit, Ilgın Yıldırım Şimşir, Füsun Saygılı, Banu Sarer Yürekli. Assessment of serum bisphenol a levels in autoimmune thyroiditis: A case-control study. EJM. 2025 Mar. 1;64(1):15-20. doi:10.19161/etd.1544200