Kronik karaciğer hastalıklarında FIB-4 ve APRI skorlarının klinik tanı ile uyumu

Pınar Peker; İbrahim Hatemi

doi:10.19161/etd.1554585

EN TR

Relationship with FIB-4, APRI scores and the clinical diagnosis in chronic liver diseases

Abstract

AİM: Liver biopsy is the gold standard for the diagnosis of cirrhosis, but has limitations such as invasive procedure, high cost, risk of rare but potentially life-threatening complications. These limitations of liver biopsy promote the development of noninvasive methods for assessments of cirrhosis. Among this models, aspartate transaminase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4) are commonly used for identifying liver fibrosis and cirrhosis in patients with chronic hepatitis B (HBV) and C virus (HCV) infection. The aim of this study was to evaluate the performance of APRI and FIB-4 to predict cirrhosis in chronic liver diseases of various etiologies. MATERIAL AND METHOD: To propose a new set of cut-offs with high specificity and sensitivity for use in clinical practice, we evaluated new cut-offs of APRI and FIB-4 patients with chronic liver diseases. FINDINGS: Based on ROC analysis, the optimal cut-offs were 1.32 for APRI, and 4.24 for FIB-4, for diagnosing cirrhosis in this study. CONCLUSİON:The more frequent use of these non-invasive methods in clinical practice will lead to the early identification of cirrhosis, and prevent unnecessary biopsy with significant complications.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Gastroenterology and Hepatology

Journal Section

Research Article

Authors

Pınar Peker ^*
0009-0004-8769-1584
Türkiye

İbrahim Hatemi
0000-0002-8385-9253
Türkiye

Publication Date

June 10, 2025

Submission Date

September 23, 2024

Acceptance Date

February 17, 2025

Published in Issue

Year 1970 Volume: 64 Number: 2

DOI

https://doi.org/10.19161/etd.1554585

IZ

https://izlik.org/JA58TP79WJ

Cite

RIS / Bibtex

Vancouver

1.Pınar Peker, İbrahim Hatemi. Kronik karaciğer hastalıklarında FIB-4 ve APRI skorlarının klinik tanı ile uyumu. EJM. 2025 Jun. 1;64(2):274-82. doi:10.19161/etd.1554585

Relationship with FIB-4, APRI scores and the clinical diagnosis in chronic liver diseases

Relationship with FIB-4, APRI scores and the clinical diagnosis in chronic liver diseases

Abstract

Keywords