Kronik karaciğer hastalıklarında FIB-4 ve APRI skorlarının klinik tanı ile uyumu

Pınar Peker; İbrahim Hatemi

doi:10.19161/etd.1554585

EN TR

Relationship with FIB-4, APRI scores and the clinical diagnosis in chronic liver diseases

Abstract

AİM: Liver biopsy is the gold standard for the diagnosis of cirrhosis, but has limitations such as invasive procedure, high cost, risk of rare but potentially life-threatening complications. These limitations of liver biopsy promote the development of noninvasive methods for assessments of cirrhosis. Among this models, aspartate transaminase-to-platelet ratio index (APRI) and fibrosis index based on four factors (FIB-4) are commonly used for identifying liver fibrosis and cirrhosis in patients with chronic hepatitis B (HBV) and C virus (HCV) infection. The aim of this study was to evaluate the performance of APRI and FIB-4 to predict cirrhosis in chronic liver diseases of various etiologies. MATERIAL AND METHOD: To propose a new set of cut-offs with high specificity and sensitivity for use in clinical practice, we evaluated new cut-offs of APRI and FIB-4 patients with chronic liver diseases. FINDINGS: Based on ROC analysis, the optimal cut-offs were 1.32 for APRI, and 4.24 for FIB-4, for diagnosing cirrhosis in this study. CONCLUSİON:The more frequent use of these non-invasive methods in clinical practice will lead to the early identification of cirrhosis, and prevent unnecessary biopsy with significant complications.

Keywords

Kronik karaciğer hastalıklarında FIB-4 ve APRI skorlarının klinik tanı ile uyumu

Öz

Amaç: Karaciğer biyopsisi, siroz tanısında altın standart yöntem olmasına rağmen invazif olması, nadir ancak yaşamı tehdit edici komplikasyonlara neden olması gibi bazı sınırlılıkları bulunmaktadır. Karaciğer biyopsisinin bu sınırlılıkları siroz tanısında kullanılabilecek invazif olmayan yöntemlerin geliştirilmesini gerektirmektedir. Bu invazif olmayan yöntemler arasında aspartat transaminazın platelete oranı (APRI) ve dört faktörü temel alan fibrozis indeksi (FIB-4) kronik hepatit B (HBV) ve C (HCV) hastalarında fibrozis ve sirozun tanımlanmasında sık tercih edilmektedir. Gereç ve Yöntem: Bu çalışmanın amacı çeşitli etiyolojilerdeki kronik karaciğer hastalarında APRI ve FIB-4’ün sirozun tahmin edilmesindeki performansını değerlendirmektir. Çalışmamızda klinik pratikte kullanım için yüksek sensitivite ve spesifitede yeni eşik değerler oluşturmak için kronik karaciğer hastalarında APRI ve FIB-4’ün yeni eşik değerleri analiz ettik. Bulgular: Çalışmamızda ROC analizlerinde, siroz tanısı için optimal eşik değerin APRI için 1,32, FIB-4 için 4,24 olduğu görüldü. Sonuç: Bu invazif olmayan yöntemlerin daha sık kullanımı sirozun erken tanınmasını ve önemli komplikasyonları olan gereksiz biyopsilerin önlenmesini sağlayacaktır.

Anahtar Kelimeler

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Details

Primary Language

Turkish

Subjects

Gastroenterology and Hepatology

Journal Section

Research Article

Authors

Pınar Peker ^*
0009-0004-8769-1584
Türkiye

İbrahim Hatemi
0000-0002-8385-9253
Türkiye

Publication Date

June 10, 2025

Submission Date

September 23, 2024

Acceptance Date

February 17, 2025

Published in Issue

Year 2025 Volume: 64 Number: 2

DOI

https://doi.org/10.19161/etd.1554585

IZ

https://izlik.org/JA58TP79WJ

Cite

RIS / Bibtex

Vancouver

1.Pınar Peker, İbrahim Hatemi. Kronik karaciğer hastalıklarında FIB-4 ve APRI skorlarının klinik tanı ile uyumu. EJM. 2025 Jun. 1;64(2):274-82. doi:10.19161/etd.1554585