Role of hematologic parameters in predicting early pregnancy loss

Can Ata; Ufuk Atlıhan; Onur Yavuz; Alper İleri; Hüseyin Aytuğ Avşar; Mehmet Emre Peker; Tevfik Berk Bıldacı; Selçuk Erkılınç

doi:10.19161/etd.1651155

TR EN

Erken gebelik kaybını tahmin etmede hematolojik parametrelerin rolü

Öz

Amaç: Çalışmamızın amacı erken gebelik kaybını tahmin etmede hematolojik parametrelerin rolünü araştırmaktır. Gereç ve Yöntem: Ocak 2021-2024 tarihleri arasında hastanemize başvuran, gebelik kesesi ölçümleri 6-7 hafta aralığında olan, yaşları 18-45 arasında değişen 284 gebe çalışmaya dahil edildi. Erken gebelik kaybı geçiren 133 gebe çalışma grubuna dahil edilirken, kontrol grubunu ≥37 hafta doğum yapan 151 sağlıklı gebe oluşturdu. Erken gebelik kaybı yaşayan gebeler ile ≥37 hafta doğum yapan gebeler karşılaştırıldı. Tüm hastaların yaş, vücut kitle indeksi, gravida, parite, abortus, sigara içme durumu ve hematolojik parametreleri retrospektif olarak değerlendirildi. Bulgular: SII ve SIRI, erken gebelik kaybı grubunda kontrol grubuna göre anlamlı derecede daha yüksek saptandı (p=0.044, p=0.042, sırasıyla). PIV, erken gebelik kaybı grubunda grubunda kontrol grubuna göre anlamlı derecede daha yüksek saptandı (p=0.048). Gruplar arasında NLR, PLR, MLR ve MPV açısından anlamlı bir fark saptanmadı. Sonuç: SII, SIRI ve PIV gibi hematolojik parametreler erken gebelik kaybıyla ilişkili inflamatuar süreçler hakkında değerli bilgiler sağlar. Bu parametrelerin rutin doğum öncesi tarama protokollerine entegre edilmesi, kayıp riski taşıyan gebeliklerin erken tespitini ve yönetimini iyileştirebilir. Standart eşik değerlerini belirlemek için daha fazla çalışmaya ihtiyaç vardır.

Anahtar Kelimeler

Role of hematologic parameters in predicting early pregnancy loss

Abstract

Aim: To investigate the role of hematologic parameters in predicting early pregnancy loss (EPL). Materials and Methods: Two hundred eighty-four pregnant women aged between 18 and 45 years who were admitted to our hospital between January 2021-2024 and whose gestational sac measurements were in the 6th-7th weeks, were included in the study. One hundred thirty-three pregnant women who experienced EPL were included in the study group, and the control group consisted of 151 healthy pregnant women who gave birth at ≥37 weeks. Pregnant women who experienced EPL and those who give birth at ≥37 weeks were compared. Age, body mass index (BMI), gravida, parity, abortion, smoking status, and hematologic parameters of all patients were evaluated retrospectively. Results: SII was significantly higher in the EPL group compared with the control group (p=0.044). SIRI was significantly higher in the EPL group compared with the control group (p=0.042). PIV was significantly higher in the EPL group compared with the control group (p=0.048). No significant difference was found in terms of NLR, PLR, MLR, and MPV between the groups. Conclusion: Hematologic parameters such as SII, SIRI, and PIV provide valuable information about inflammatory processes associated with early pregnancy loss. Integration of these parameters into routine prenatal screening protocols may improve the early detection and management of pregnancies at risk of loss. Further studies are needed to determine standard threshold values.

Keywords

References

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Details

Primary Language

English

Subjects

Obstetrics and Gynaecology

Journal Section

Research Article

Authors

Can Ata
0000-0002-0841-0480
Türkiye

Ufuk Atlıhan ^*
0000-0002-2109-1373
Türkiye

Onur Yavuz
0000-0003-3716-2145
Türkiye

Alper İleri
0000-0002-4713-5805
Türkiye

Hüseyin Aytuğ Avşar
0000-0003-0636-3104
Türkiye

Mehmet Emre Peker
0000-0002-3344-2935
Türkiye

Tevfik Berk Bıldacı
0000-0002-6432-6777
Türkiye

Selçuk Erkılınç
0000-0002-6512-9070
Türkiye

Publication Date

September 8, 2025

Submission Date

March 14, 2025

Acceptance Date

May 13, 2025

Published in Issue

Year 2025 Volume: 64 Number: 3

DOI

https://doi.org/10.19161/etd.1651155

IZ

https://izlik.org/JA54HD27TE

Cite

RIS / Bibtex

Vancouver

1.Can Ata, Ufuk Atlıhan, Onur Yavuz, Alper İleri, Hüseyin Aytuğ Avşar, Mehmet Emre Peker, Tevfik Berk Bıldacı, Selçuk Erkılınç. Role of hematologic parameters in predicting early pregnancy loss. EJM. 2025 Sep. 1;64(3):504-9. doi:10.19161/etd.1651155