Yoğun bakım hastalarında RIFLE sınıflandırmasına göre akut böbrek yetmezliği gelişme insidansı: Retrospektif çalışma

Nursen Karaca; Kubilay Demirağ; Canan Bor; İlkin Çankayalı; Mehmet Uyar

doi:10.19161/etd.1659202

TR EN

Yoğun bakım hastalarında RIFLE sınıflandırmasına göre akut böbrek yetmezliği gelişme insidansı: Retrospektif çalışma

Öz

Amaç: Çalışmamızda RIFLE kriterlerini kullanılarak, yoğun bakım hastalarında akut böbrek hasarı gelişme insidansı, risk faktörleri ve mortalite ile olan ilişkisini değerlendirmeyi hedefledik. Gereç ve Yöntem: Hastanemiz etik kurul onay belgesi alındıktan sonra (10-9/3, 27.09.2010) anestezi yoğun bakım ünitesine bir yıl içinde başvuran hastaların dosyaları retrospektif olarak incelendi. Hastalar serum kreatinin değeri, idrar çıkışı ve glomerüler filtrasyon hızına göre; RIFLE dışı, R (risk), I (ınjury), F (failure), L (loss of kidney function) ve E (end stage kidney disease) olarak gruplara ayrıldı. Demografik veriler, primer tanı, vazopressör ve diüretik ilaç kullanımı, renal replasman tedavisi, APACHE II skoru, yoğun bakım yatış süresi ve sonuç bilgileri hasta dosyalarından kaydedildi. Bulgular: Çalışma süresince 522 hasta yoğun bakım ünitesine kabul edildi, 214’ü çalışmaya dahil edildi. Hastaların %79,9’ unda akut böbrek hasarı görülmüş olup maksimum RIFLE kriterlerine göre dağılımları; R %26,6, I %14,9, F %37,9, L %0,5 şeklindeydi. Hiçbir hastada son dönem böbrek yetmezliği (E) gelişmezken, %20,1 hasta RIFLE sınıf dışı olarak bulundu. Çalışmamızda RIFLE sınıflamasına göre mortalite oranları; Risk grubunda %16,1, injury grubunda %17,0 ve failure grubunda %63,4 iken RIFLE sınıflaması dışında kalan grupta %3,6 olarak bulundu (p<0,001). Sonuç: RIFLE sınıflaması ile yoğun bakımdaki mortalite oranları arasında anlamlı bir ilişki olduğu, RIFLE şiddet derecesi arttıkça mortalite oranının arttığı gösterilmiştir.

Anahtar Kelimeler

Incidence of acute kidney ınjury in ıntensive care unit patients according to RIFLE classification: A retrospective study

Abstract

Aim: The aim of this study is to assess the incidence of acute kidney injury, evaluate its risk factors, and investigate the association with mortality among patients in intensive care units, utilizing the RIFLE criteria. Materials and Methods: The study protocol received approval from the ethics committee at Ege University (10-9/3, 27.09.2010). Records of all patients admitted to the intensive care unit over the course of one year were reviewed retrospectively. Patients were categorized into groups based on the RIFLE classification: non-RIFLE, risk (R), injury (I), failure (F), loss of kidney function (L), and end-stage kidney disease (E). This classification was determined by serum creatinine levels, urine output, and glomerular filtration rate values. Variables such as demographic data, primary diagnoses, vasopressor use, diuretics use, renal replacement therapy, APACHE II score, length of stay in intensive care unit and outcome were collected from patient medical charts. Results: Out of 522 patients admitted to the intensive care unit, only 214 were subsequently included in the study. Acute kidney injury was found in 79.9% of patients, with the RIFLE categories as follows: 20.1% non-RIFLE, 26.6% in R, 14.9% in I, 37.9% in F and 0.5% in L. None progressed to end-stage kidney disease. Mortality rates varied: 3.6% for non-RIFLE, 16.1% for R, 17.0% for I and 63.4% for F group (p < 0.001). Conclusion: There is a strong correlation between the RIFLE classification and mortality rates in the intensive care unit. As the severity of the RIFLE class increases, the mortality rate correspondingly increases.

Keywords

References

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Details

Primary Language

Turkish

Subjects

Anaesthesiology , Intensive Care

Journal Section

Research Article

Authors

Nursen Karaca ^*
0000-0001-7188-9001
Türkiye

Kubilay Demirağ
0000-0003-1311-7972
Türkiye

Canan Bor
0000-0001-7658-2113
Türkiye

İlkin Çankayalı
0000-0003-1441-5584
Türkiye

Mehmet Uyar
0000-0001-9292-2616
Türkiye

Publication Date

September 8, 2025

Submission Date

March 18, 2025

Acceptance Date

May 5, 2025

Published in Issue

Year 2025 Volume: 64 Number: 3

DOI

https://doi.org/10.19161/etd.1659202

IZ

https://izlik.org/JA36PD26SP

Cite

RIS / Bibtex

Vancouver

1.Nursen Karaca, Kubilay Demirağ, Canan Bor, İlkin Çankayalı, Mehmet Uyar. Yoğun bakım hastalarında RIFLE sınıflandırmasına göre akut böbrek yetmezliği gelişme insidansı: Retrospektif çalışma. EJM. 2025 Sep. 1;64(3):452-9. doi:10.19161/etd.1659202