A review of exosomes derived from mesenchymal stem cells as a treatment approach for temporomandibular disorders

Fulya Gürcan; Deniz Özen; Gözde Işık; Yiğit Uyanıkgil

doi:10.19161/etd.1759166

EN TR

A review of exosomes derived from mesenchymal stem cells as a treatment approach for temporomandibular disorders

Abstract

Stem cell-based therapies are contemporary approaches that particularly involve the use of mesenchymal stem cells. Mesenchymal stem cells are multipotent precursors capable of differentiating from various cell sources, including adipocytes, myocytes, osteoblasts, and chondrocytes. They have self-renewal capabilities and possess properties that support hemostasis, reduce inflammation, modulate the immune response, and promote tissue regeneration. The paracrine activity of mesenchymal stem cells serves as a significant mechanism for their therapeutic efficacy. Recently, there has been a growing interest in the secretomes of mesenchymal stem cells which consist of growth factors, cytokines, chemokines, and extracellular vesicles. Extracellular vesicles are classified into two subtypes: ectosomes and exosomes. These secretions hold potential as innovative tools in regenerative medicine and dentistry for diagnosing, managing, and monitoring various diseases. This review focused on mesenchymal stem cells-derived exosomes and their potential as an alternative strategy for the therapeutic management of temporomandibular disorders. It also summarized the benefits and drawbacks associated with this treatment

Keywords

Ethical Statement

This is a review article that does not require ethical approval

References

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Details

Primary Language

English

Subjects

Facial Plastic Surgery , Regenerative Medicine (Incl. Stem Cells)

Journal Section

Review

Authors

Fulya Gürcan ^*
0009-0000-6787-1685
Türkiye

Deniz Özen
0009-0009-7192-9208
Türkiye

Gözde Işık
0000-0001-9572-3049
Türkiye

Yiğit Uyanıkgil
0000-0002-4016-0522
Türkiye

Publication Date

March 9, 2026

Submission Date

August 7, 2025

Acceptance Date

November 18, 2025

Published in Issue

Year 1970 Volume: 65 Number: 1

DOI

https://doi.org/10.19161/etd.1759166

IZ

https://izlik.org/JA29UD62UT

Cite

RIS / Bibtex

Vancouver

1.Fulya Gürcan, Deniz Özen, Gözde Işık, Yiğit Uyanıkgil. A review of exosomes derived from mesenchymal stem cells as a treatment approach for temporomandibular disorders. EJM. 2026 Mar. 1;65(1):194-205. doi:10.19161/etd.1759166

A review of exosomes derived from mesenchymal stem cells as a treatment approach for temporomandibular disorders

A review of exosomes derived from mesenchymal stem cells as a treatment approach for temporomandibular disorders

Abstract

Keywords

Temporomandibular eklem bozukluklarında tedavi yaklaşımı olarak kullanılan mezenkimal kök hücre kaynaklı eksozomlar üzerine bir derleme

Öz

Anahtar Kelimeler

Ethical Statement

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite