A review of exosomes derived from mesenchymal stem cells as a treatment approach for temporomandibular disorders

Fulya Gürcan; Deniz Özen; Gözde Işık; Yiğit Uyanıkgil

doi:10.19161/etd.1759166

EN TR

A review of exosomes derived from mesenchymal stem cells as a treatment approach for temporomandibular disorders

Abstract

Stem cell-based therapies are contemporary approaches that particularly involve the use of mesenchymal stem cells. Mesenchymal stem cells are multipotent precursors capable of differentiating from various cell sources, including adipocytes, myocytes, osteoblasts, and chondrocytes. They have self-renewal capabilities and possess properties that support hemostasis, reduce inflammation, modulate the immune response, and promote tissue regeneration. The paracrine activity of mesenchymal stem cells serves as a significant mechanism for their therapeutic efficacy. Recently, there has been a growing interest in the secretomes of mesenchymal stem cells which consist of growth factors, cytokines, chemokines, and extracellular vesicles. Extracellular vesicles are classified into two subtypes: ectosomes and exosomes. These secretions hold potential as innovative tools in regenerative medicine and dentistry for diagnosing, managing, and monitoring various diseases. This review focused on mesenchymal stem cells-derived exosomes and their potential as an alternative strategy for the therapeutic management of temporomandibular disorders. It also summarized the benefits and drawbacks associated with this treatment

Keywords

Etik Beyan

This is a review article that does not require ethical approval

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Ağız, Yüz ve Çene Cerrahisi , Rejeneratif Tıp (kök hücreler dahil)

Bölüm

Derleme

Yazarlar

Fulya Gürcan ^*
0009-0000-6787-1685
Türkiye

Deniz Özen
0009-0009-7192-9208
Türkiye

Gözde Işık
0000-0001-9572-3049
Türkiye

Yiğit Uyanıkgil
0000-0002-4016-0522
Türkiye

Yayımlanma Tarihi

9 Mart 2026

Gönderilme Tarihi

7 Ağustos 2025

Kabul Tarihi

18 Kasım 2025

Yayımlandığı Sayı

Yıl 1970 Cilt: 65 Sayı: 1

DOI

https://doi.org/10.19161/etd.1759166

IZ

https://izlik.org/JA29UD62UT

Kaynak Göster

RIS / Bibtex

Vancouver

1.Fulya Gürcan, Deniz Özen, Gözde Işık, Yiğit Uyanıkgil. A review of exosomes derived from mesenchymal stem cells as a treatment approach for temporomandibular disorders. ETD. 01 Mart 2026;65(1):194-205. doi:10.19161/etd.1759166

Temporomandibular eklem bozukluklarında tedavi yaklaşımı olarak kullanılan mezenkimal kök hücre kaynaklı eksozomlar üzerine bir derleme

A review of exosomes derived from mesenchymal stem cells as a treatment approach for temporomandibular disorders

Abstract

Keywords

Temporomandibular eklem bozukluklarında tedavi yaklaşımı olarak kullanılan mezenkimal kök hücre kaynaklı eksozomlar üzerine bir derleme

Öz

Anahtar Kelimeler

Etik Beyan

Kaynakça

Ayrıntılar

Birincil Dil

Konular

Bölüm

Yazarlar

Yayımlanma Tarihi

Gönderilme Tarihi

Kabul Tarihi

Yayımlandığı Sayı

DOI

IZ

Kaynak Göster