Erken evre ağız boşluğu kanserlerinde lizil oksidazların boyun metastazı ve prognoz ile ilişkisinin araştırılması
Abstract
Ağız boşluğu kanserleri (AK), özellikle tütün kullanımı, alkol tüketimi ve HPV’den bağımsız karsinojenik yolların görülme sıklığını artırdığı bölgelerde önemli bir küresel sağlık sorunu olmaya devam etmektedir. Bu bağlamda, hem primer tümör agresifliği hem de boyun metastazı eğilimi için potansiyel biyobelirteçler olarak lizil oksidazın (LOX) ve onun paralogu LOX benzeri 2'nin (LOX 2) post translasyonel modifiye (PTM) proteoformlarının umut verici ancak yeterince keşfedilmemiş rolünü vurguladık. Proteoform bilimi geliştikçe, bu moleküler hedeflere öncelik vermek AK araştırma topluluğunun temel odak noktası haline gelmelidir. Bunların tanı ve prognoz çerçevelerine entegre edilmesi, agresif hastalığı erken saptama ve tedavileri daha etkili bir şekilde uyarlama becerimizi önemli ölçüde geliştirebilir ve sonuç olarak hasta sağ kalımını ve yaşam kalitesini iyileştirebilir
References
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Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers
Abstract
Oral cavity cancers (OCC) remain a significant global health challenge, particularly in regions where tobacco use, alcohol consumption, and HPV independent carcinogenic pathways drive rising incidence rates. In this context, we highlighted the promising yet underexplored role of post
translationally modified (PTM) proteoforms of lysyl oxidase (LOX) and its paralog LOX like 2 (LOX 2) as potential biomarkers for both primary tumor aggressiveness and propensity for neck metastasis. As proteoform science evolves, prioritizing these molecular targets should become a key focus for the OCC research community. Their integration into diagnostic and prognostic frameworks may significantly enhance our ability to detect aggressive disease early and tailor treatments more effectively, ultimately improving patient survival and quality of life.
Ethical Statement
Not applicable.
References
- Ebrahimi R, Masouri MM, Razeghian I, Azad G, Nejadghaderi SA. Lip, Oral Cavity, and Pharyngeal Cancers: Global Epidemiology, Risk Factors, and Prevention: A Narrative Review. Health Sci Rep. 2025;8(10):e71289. doi: 10.1002/hsr2.71289.
- Şahin VE, Öztürk K, Turhal G, Veral A. Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers. EJM. 2025;64(3):431-7.
- Luo RY, Yeung PSW, Mann MW, Zhang L, Yang YK, Hoofnagle AN. Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use. Clin Chem. 2025 Nov 4;71(11):1111-1124. doi: 10.1093/clinchem/hvaf094.
- Tenti P, Vannucci L. Lysyl oxidases: linking structures and immunity in the tumor microenvironment. Cancer Immunol Immunother. 2020 Feb;69(2):223-235. doi: 10.1007/s00262-019-02404-x.
- Williams AA, Firenza KN, Carfagno AK, Kline JT, Fornelli L. Comparative Analysis of Proteoform Clean-Up Methods for In-Depth Top-Down Proteomics. Proteomics. 2025 Nov 10:e70067. doi: 10.1002/pmic.70067.
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Chemistry |
| Journal Section | Letter to Editor |
| Authors | |
| Submission Date | December 9, 2025 |
| Acceptance Date | January 8, 2026 |
| Publication Date | March 9, 2026 |
| DOI | https://doi.org/10.19161/etd.1838972 |
| IZ | https://izlik.org/JA86LW87YK |
| Published in Issue | Year 2026 Volume: 65 Issue: 1 |
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