TR
EN
Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers
Abstract
Oral cavity cancers (OCC) remain a significant global health challenge, particularly in regions where tobacco use, alcohol consumption, and HPV independent carcinogenic pathways drive rising incidence rates. In this context, we highlighted the promising yet underexplored role of post
translationally modified (PTM) proteoforms of lysyl oxidase (LOX) and its paralog LOX like 2 (LOX 2) as potential biomarkers for both primary tumor aggressiveness and propensity for neck metastasis. As proteoform science evolves, prioritizing these molecular targets should become a key focus for the OCC research community. Their integration into diagnostic and prognostic frameworks may significantly enhance our ability to detect aggressive disease early and tailor treatments more effectively, ultimately improving patient survival and quality of life.
Keywords
Ethical Statement
Not applicable.
References
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- Luo RY, Yeung PSW, Mann MW, Zhang L, Yang YK, Hoofnagle AN. Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use. Clin Chem. 2025 Nov 4;71(11):1111-1124. doi: 10.1093/clinchem/hvaf094.
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- Williams AA, Firenza KN, Carfagno AK, Kline JT, Fornelli L. Comparative Analysis of Proteoform Clean-Up Methods for In-Depth Top-Down Proteomics. Proteomics. 2025 Nov 10:e70067. doi: 10.1002/pmic.70067.
Details
Primary Language
English
Subjects
Clinical Chemistry
Journal Section
Letter to Editor
Publication Date
March 9, 2026
Submission Date
December 9, 2025
Acceptance Date
January 8, 2026
Published in Issue
Year 2026 Volume: 65 Number: 1