TR
EN
Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers
Abstract
Oral cavity cancers (OCC) remain a significant global health challenge, particularly in regions where tobacco use, alcohol consumption, and HPV independent carcinogenic pathways drive rising incidence rates. In this context, we highlighted the promising yet underexplored role of post
translationally modified (PTM) proteoforms of lysyl oxidase (LOX) and its paralog LOX like 2 (LOX 2) as potential biomarkers for both primary tumor aggressiveness and propensity for neck metastasis. As proteoform science evolves, prioritizing these molecular targets should become a key focus for the OCC research community. Their integration into diagnostic and prognostic frameworks may significantly enhance our ability to detect aggressive disease early and tailor treatments more effectively, ultimately improving patient survival and quality of life.
Keywords
Etik Beyan
Not applicable.
Kaynakça
- Ebrahimi R, Masouri MM, Razeghian I, Azad G, Nejadghaderi SA. Lip, Oral Cavity, and Pharyngeal Cancers: Global Epidemiology, Risk Factors, and Prevention: A Narrative Review. Health Sci Rep. 2025;8(10):e71289. doi: 10.1002/hsr2.71289.
- Şahin VE, Öztürk K, Turhal G, Veral A. Investigation of the relationship of lysyl oxidases on neck metastasis and prognosis in early stage oral cavity cancers. EJM. 2025;64(3):431-7.
- Luo RY, Yeung PSW, Mann MW, Zhang L, Yang YK, Hoofnagle AN. Post-Translationally Modified Proteoforms as Biomarkers: From Discovery to Clinical Use. Clin Chem. 2025 Nov 4;71(11):1111-1124. doi: 10.1093/clinchem/hvaf094.
- Tenti P, Vannucci L. Lysyl oxidases: linking structures and immunity in the tumor microenvironment. Cancer Immunol Immunother. 2020 Feb;69(2):223-235. doi: 10.1007/s00262-019-02404-x.
- Williams AA, Firenza KN, Carfagno AK, Kline JT, Fornelli L. Comparative Analysis of Proteoform Clean-Up Methods for In-Depth Top-Down Proteomics. Proteomics. 2025 Nov 10:e70067. doi: 10.1002/pmic.70067.
Ayrıntılar
Birincil Dil
İngilizce
Konular
Klinik Kimya
Bölüm
Editöre Mektup
Yayımlanma Tarihi
9 Mart 2026
Gönderilme Tarihi
9 Aralık 2025
Kabul Tarihi
8 Ocak 2026
Yayımlandığı Sayı
Yıl 2026 Cilt: 65 Sayı: 1