OUANTITATIVE ASSESSMENT OF HIPPOCAMPUS CA1 DAMAGING FOLLOW!NG MATERNALLY APPLICATION OF HIGH DOSE OF RETINOL ACETATE

Volume: 40 Number: 2 June 1, 2001
  • Hüseyin Aktuğ
  • Mine Ertem Yurtseven
  • Mert Göl
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OUANTITATIVE ASSESSMENT OF HIPPOCAMPUS CA1 DAMAGING FOLLOW!NG MATERNALLY APPLICATION OF HIGH DOSE OF RETINOL ACETATE

Abstract

İn this study quantitative examination of dose dependent teratogenic effect of maternally applied Retinol Acetate (Vit A) on central nerve system and especially on variations caused at the tissue of the hippocampus was aimed. After maternally intraperitoneal application of single doses of 40000 ILJ/kg retinol asetat, 160000 IU/kg retinol acetate and %0.9 serum physiologic (control group) waited untii the pregnarıcy was över. Postnatal first day after the intracardiac perfusion process, the hippocampal tissues of nevvborn rats dissected and after their follow-ups under a lıght microscope were accomplished the preparations made were examined as 100 times magnified. The cells wiih edema and the cells wıthin the normal configuration were counted and the morphometric analysis statistically accomplished. Statistically significant differences betvveen control group and retinol acetate giyen groups were detected.

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Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Hüseyin Aktuğ

Mine Ertem Yurtseven

Mert Göl

Publication Date

June 1, 2001

Submission Date

June 1, 2001

Acceptance Date

-

Published in Issue

Year 2001 Volume: 40 Number: 2

IZ

https://izlik.org/JA24BS35SA

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1.Hüseyin Aktuğ, Mine Ertem Yurtseven, Mert Göl. MATERNAL OLARAK YÜKSEK DOZ RETİNOL ASETAT UYGULANIMINI TAKİBEN, SIÇAN HİPOKAMPUS CA1 HASARLANMASINÎN KANTİTATİF DEĞERLENDİRİLMESİ. EJM [Internet]. 2001 Jun. 1;40(2):83-6. Available from: https://izlik.org/JA24BS35SA

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