HISTOLOGICAL CHANGES IN THE RAT STOMACH AFTER CHRONIC NITRIC OXIDE SYNTHASE INHIBITION

Volume: 40 Number: 3 September 1, 2001
  • - Feralöztürk
  • Ersin Fadıllıoğlu
  • Murat Yağmurca
  • Meltem Kuruş
  • Nigar Vardı
  • M. Hanifi Emre
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HISTOLOGICAL CHANGES IN THE RAT STOMACH AFTER CHRONIC NITRIC OXIDE SYNTHASE INHIBITION

Abstract

We examined the histological changes in the rat stomachs, follovving chronic nitric oxide synthase (NOS) inhibition with the administration of hf-nitro-L-arginine methyl ester (L-NAME), for two weeks. Fifteen adult female VVistar albino rats were divided into three groups. Group I was the control group. Group II and III received 100mg/L and 500mg/L L-NAME respectively, with their drinking vvaters. With light microscopy, the stomach histology were found normal in groups I and II. İn group III, parietal cells found more numerous in the bases of the gastric glands and some of the gastric glands shovved local dilatations. Gland cells were atrofic around the dilated lumens. İn corpus glands, the secretions of ali the neck mucous cells, were periodic acid-Schiff (PAS) negative in group III, vvhile they vvere PAS positive in groups I and II. İn conclusion, it has been observed that chronic NOS inhibition alters rat stomach microscopy.

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Primary Language

Turkish

Subjects

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Journal Section

-

Authors

- Feralöztürk

Ersin Fadıllıoğlu

Murat Yağmurca

Meltem Kuruş

Nigar Vardı

M. Hanifi Emre

Publication Date

September 1, 2001

Submission Date

September 1, 2001

Acceptance Date

-

Published in Issue

Year 2001 Volume: 40 Number: 3

IZ

https://izlik.org/JA38GK83ZT

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Vancouver
1.- Feralöztürk, Ersin Fadıllıoğlu, Murat Yağmurca, Meltem Kuruş, Nigar Vardı, M. Hanifi Emre. KRONİK NİTRİK OKSİT SENTAZ İNHİBİSYONUNUN SIÇAN MİDESİNDE MEYDANA GETİRDİĞİ HİSTOLOJİK DEĞİŞİKLİKLER. EJM [Internet]. 2001 Sep. 1;40(3):145-9. Available from: https://izlik.org/JA38GK83ZT

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