IMPORTANCE OF CATHEPSIN D1 AND GENETİC HETEROGENEITY FROM PROGNOSTIC FACTORS IN RENAL CELL CARCINOMA

Volume: 40 Number: 3 September 1, 2001
  • Meral Koyuncuoğlu
  • Mustafa Pehlivan
  • Sacide Pehlivan
  • Ziya Kırkalı
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IMPORTANCE OF CATHEPSIN D1 AND GENETİC HETEROGENEITY FROM PROGNOSTIC FACTORS IN RENAL CELL CARCINOMA

Abstract

Renal celi carcinomas (RCC) are tumors, which are very different from other human cancers in terms of their de meanor. The most important prognostic factors in the clinical evaluation are tumor stage and nuclear grade. in other tumors, the prognostic importance of cathepsin D1 (CD) expression is controversial. İn most studies. though stressed to be bad prognostic factor, CD and genetic heterogeneity (GH) as a prognostic factor in RCC have not been studied. In this study 48 cases under regular control with a diagnosis of RCC by radical nephrectomy were examined. Their median age was 56.5 (31-79); 28 were men (58%). The period of median follow-up is 51 months. When 18 different clinical and laboratory parameters were evaluated as prognostic factorin univariate analysis, CD and advanced stage were found to be significant prognostic factor affecting 5-yr survival rate negatively (p=0. 046, p=:0. 021). Furthermore, in the group in which GH was found in microsatellite D9S157, close to the area coding the enzymes responsible for RNA processing and DNA repairing, the 5- year survival rate, though statistically insignificant, was found to be shorter. In conclusion, in addition to commonly known prognostic should also consider CD in predicting prognosis.

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Primary Language

Turkish

Subjects

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Journal Section

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Authors

Meral Koyuncuoğlu

Mustafa Pehlivan

Sacide Pehlivan

Ziya Kırkalı

Publication Date

September 1, 2001

Submission Date

September 1, 2001

Acceptance Date

-

Published in Issue

Year 2001 Volume: 40 Number: 3

IZ

https://izlik.org/JA83HR23FW

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1.Meral Koyuncuoğlu, Mustafa Pehlivan, Sacide Pehlivan, Ziya Kırkalı. BÖBREĞİN RENAL HÜCRELİ KANSERLERİNDE PROGNOSTİK FAKTÖRLERDEN CATHEPSİN D1 EKSPRESYONU VE GENETİK HETEROJENİTENİN ÖNEMİ. EJM [Internet]. 2001 Sep. 1;40(3):151-7. Available from: https://izlik.org/JA83HR23FW

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