EXPRESSION OF p53 PROTEIN IN ADENOCARCINOMAS OF STOMACH AND ITS RELATIONSHIP WITH OTHER CONVENTIONAL PROGNOSTIC FACTORS

Volume: 41 Number: 1 March 1, 2002
  • Aylin Örgen Çallı
  • Neşe Ekinci
  • Ayşegül Akder Sarı
  • Filiz Dağ
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EXPRESSION OF p53 PROTEIN IN ADENOCARCINOMAS OF STOMACH AND ITS RELATIONSHIP WITH OTHER CONVENTIONAL PROGNOSTIC FACTORS

Abstract

Mutations of the p53 gene belong to the most common genetic alterations in human cancer that have been implicated in tumorigenesis and tumor progression. Although p53 expression appears to be correlated with prognosis of breast cancer and some other types of cancer, its prognostic role in gastric cancer is stili uncertain. p53 gene expression was examined in formalin-fixed, paraffin-embedded tissue sections from 70 patients with gastric cancer. p53 expression was detected in 31% of ali tumors. The correlation of p53 over-expression and depth of invasion, lymph node involvement, degree of tumor differantion, blood vessel invasion, lymphatic vessel invasion, age , sex and tumor size was evaluated statistically. Significant relation was not noted between p53 expression and prognostic factors except histologic grade. These results indicate p53 expression seem to be important in the prognosis of only intestinal type of gastric carcinomas; hovvever, p53 protein accumulation was found to have no prognostic value in gastric tumors.

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Primary Language

Turkish

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Journal Section

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Authors

Aylin Örgen Çallı

Neşe Ekinci

Ayşegül Akder Sarı

Filiz Dağ

Publication Date

March 1, 2002

Submission Date

March 1, 2002

Acceptance Date

-

Published in Issue

Year 2002 Volume: 41 Number: 1

IZ

https://izlik.org/JA69GY45CW

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1.Aylin Örgen Çallı, Neşe Ekinci, Ayşegül Akder Sarı, Filiz Dağ. MİDE ADENOKARSİNOMLARINDA p53 EKSPRESYONU VE DİĞER KONVANSİYONEL PROGNOSTİK FAKTÖRLERLE İLİŞKİSİ. EJM [Internet]. 2002 Mar. 1;41(1):1-6. Available from: https://izlik.org/JA69GY45CW

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