DIFFICULTIES IN DIAGNOSIS OF AMYLOIDOSIS: IS IT POSSIBLE TO SPARE THE KIDNEY FROM BIOPSY?

Volume: 41 Number: 4 December 1, 2002
  • Sait Şen
  • Murat Bülent Alkanat
  • Taner Akalın
  • Nazan Özsan
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DIFFICULTIES IN DIAGNOSIS OF AMYLOIDOSIS: IS IT POSSIBLE TO SPARE THE KIDNEY FROM BIOPSY?

Abstract

Amyloidosis is a systemic disease and amyloid deposition in tissue has to be shown to reach the exact diagnosis. Ifthere is a clinical suspicion of amyloidosis, adipose tissue orrectum biopsy is preferred. If amyloid deposition can'tbe shown, renal and/or other organ biopsies are done. Minute depositions and those which are evaluated improperly, could be missed. In this study, we have investigated the necessity of renal biopsy for determination of amyloidosis, by evaluation of other biopsies ofcases with renal amyloidosis. Fifty-five cases with a diagnosis of renal amyloidosis in the last three years were included in this study. Thirty-five biopsies from other organs of the fifteen cases were reevaluated. Ofthese 35 biopsies, seven were from rectum, six from bone marrow, six rom stomach, three from liver, three from salivary gland, two from skin, two from adipose tissue, and one from bladder, muscle, jejunum, gingiva, intestine and kidney. Amyloid deposition was detected in other organ biopsies of fourteen cases. İn ten of them diagnosis could be made without renal bıopsy. Amyloid deposition was found in 6 rectum, 6 stomach, 3 salivary gland, 2 bone marrow, one skin, bladder, jejunum and kidney (without glomeruli) biopsies. İn three of the cases other biopsies were done for determination of amyloid subtype and the etiology. Incomplete data, technical problems and insufficient biopsy were the reasons that cause delay in diagnosis. Amyloidosis can be identified if the patients' other organ biopsies are reevaluated with sufficient clinical data before considering a renal biopsy. In this situation it is possible to spare the kidney from biopsy.

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Primary Language

Turkish

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Journal Section

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Authors

Sait Şen

Murat Bülent Alkanat

Taner Akalın

Nazan Özsan

Publication Date

December 1, 2002

Submission Date

December 1, 2002

Acceptance Date

-

Published in Issue

Year 2002 Volume: 41 Number: 4

IZ

https://izlik.org/JA28YF45CK

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1.Sait Şen, Murat Bülent Alkanat, Taner Akalın, Nazan Özsan. AMİLOİDOZİS TANISINDA ZORLUKLAR: BÖBREK İĞNE BİOPSİSİNDEN KAÇINILABİLİR Mİ? EJM [Internet]. 2002 Dec. 1;41(4):201-6. Available from: https://izlik.org/JA28YF45CK

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