MEME KANSERİNDE Kİ-67 EKSPRESYONU VE DİĞER PROGNOSTİK FAKTÖRLER İLE İLİŞKİSİ

Veliddin Canfeza Sezgin; Bülent Karabulut; Ulus Ali Şanlı; Rüçhan Uslu; Erdem Göker; Salahattin Sanal; Necmettin Özdemir

EN TR

KI-67 EXPRESSION IN BREAST CANCER AND ITS RELATIONSHIP WITH OTHER PROGNOSTIC FACTORS

Abstract

Human breast carcinomas are known to exhibit a broad spectrum of clinical behavior. Many attempts hava been made in ' the past to establish reliable and reproducible prognostic parameters. Lymph node invoivement, tumor grading and tumor size are accepted as the most important prognostic factors. The proliferative activity, expression of c-erbB-2 oncoprotein, steroid receptors status, p53 expression and patient age are other important prognostic factors. The use of the monoclonal antibody Ki-67 represents an easy and reliable means of assesing celi proliferation. The association between Ki-67 immunoreactivity and other prognostic variables was invastigated in 140 patient with primary breast carcinomas. Immunohistochemical procedure performed to determine Ki-67, estrogen receptor and c erbB-2 expression in ali cases. Ki-67, c-erbB-2 and estrogen receptor (ER) expression, lymph node positivity In the samples was % 64, % 71, % 34 and % 74, respectively. The chi-square P values are shoWn for the associations of Ki 67, c-erbB-2 and ER expression. The Ki-67 expression is not correlated with lymph node status and patient age.

Keywords

Ki-67, breast carcinoma, c-erbB-2, estrogen receptor

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Veliddin Canfeza Sezgin

Bülent Karabulut

Ulus Ali Şanlı

Rüçhan Uslu

Erdem Göker

Salahattin Sanal

Necmettin Özdemir

Publication Date

September 1, 2003

Submission Date

September 1, 2003

Acceptance Date

-

Published in Issue

Year 2003 Volume: 42 Number: 3

IZ

https://izlik.org/JA77WK93NX

Cite

RIS / Bibtex

Vancouver

1.Veliddin Canfeza Sezgin, Bülent Karabulut, Ulus Ali Şanlı, Rüçhan Uslu, Erdem Göker, Salahattin Sanal, Necmettin Özdemir. MEME KANSERİNDE Kİ-67 EKSPRESYONU VE DİĞER PROGNOSTİK FAKTÖRLER İLE İLİŞKİSİ. EJM [Internet]. 2003 Sep. 1;42(3):173-7. Available from: https://izlik.org/JA77WK93NX

KI-67 EXPRESSION IN BREAST CANCER AND ITS RELATIONSHIP WITH OTHER PROGNOSTIC FACTORS

Abstract

Keywords