EFFECT OF CEFIXIME TREATMENT ON URINARY NAG EXCRETION IN CHILDREN WITH URINARY TRACT INFECTION

Volume: 43 Number: 2 June 1, 2004
  • İpek Akil
  • Püreda Yazıcı
  • Özge Yılmaz
  • Muzaffer Polat
  • Cevval Ulman
  • Fatma Z. Kutay
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EFFECT OF CEFIXIME TREATMENT ON URINARY NAG EXCRETION IN CHILDREN WITH URINARY TRACT INFECTION

Abstract

Urinary tract infections are one of the most common bacterial infections of childhood. Efficacy of cefixime, which is a third generation cephalosporin, is proven in oral treatment of urinary tract infections. The aim of this study was to evaluate the effect of cefixime, which was shown to accumulate in renal tissue at high concentrations, on the excretion of N-acetylbeta- D-glucosaminidase (NAG) that is a sensitive marker of proximal tubular functions. The study group consisted of 26 children (age range 5-156 months, median age 72 month, 24 female) who received cefixime treatment for urinary tract infection. Control group was composed of 17 children (age range 8-156 months, median age 82 month, 6 female) whose mean age was similar to that of the patient group and who had not received antibiotics in the last month. Sodium, potassium, calcium, magnesium, uric acid, phosphorus (Na, K, Ca, Mg, UA, P) and NAG levels were measured in the first morning fasting urine in the patients before and 10 days after treatment as well as in the control group and the results were calculated by dividing these values by the urinary creatinine (Cr). Urinary levels of the NAG enzyme were measured via the paranitrophenol method after gel filtration. Results of the control and pretreatment group were compared by the Mann Whitney U test. Pre- and post-treatment urinary electrolyte and urinary NAG results were compared by the Wilcoxon Signed Ranks test.Ratio of urinary Na, K, Ca, uric acid, Mg, P and NAG to creatinin in the pretreatment group were not found to be different from those of the control group (p>0,05). Similarly, excretion of electrolytes and NAG did not change significantly after treatment when compared to those before treatment (p>0,05).As a conclusion, cefixime, which has single oral daily dosage and therefore high patient compliance, was detected not to cause changes in renal tubular functions. This result was thought to be important in determination of the safety of the treatment.

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Primary Language

Turkish

Subjects

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Journal Section

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Authors

İpek Akil

Püreda Yazıcı

Özge Yılmaz

Muzaffer Polat

Cevval Ulman

Fatma Z. Kutay

Publication Date

June 1, 2004

Submission Date

June 1, 2004

Acceptance Date

-

Published in Issue

Year 2004 Volume: 43 Number: 2

IZ

https://izlik.org/JA57UJ38SK

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1.İpek Akil, Püreda Yazıcı, Özge Yılmaz, Muzaffer Polat, Cevval Ulman, Fatma Z. Kutay. İDRAR YOLU ENFEKSİYONLU ÇOCUKLARDA SEFİKSİM TEDAVİSİNİN İDRAR NAG ATILIMINA ETKİSİ. EJM [Internet]. 2004 Jun. 1;43(2):101-4. Available from: https://izlik.org/JA57UJ38SK

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