A STUDY ON THE STRUCTURAL CHANGES OF ZONULA OCCLUDENS (TIGHT JUNCTION) BY HYPERGRAVITY DURING DEVELOPMENTAL PERIOD OF NEWBORN RAT BRAIN

Volume: 43 Number: 3 September 1, 2004
  • M. İbrahim Tuğlu
  • Enis Cezayirli
  • Tuncay Varol
  • Ertuğrul Tatlısumak
  • Seda Vatansever
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A STUDY ON THE STRUCTURAL CHANGES OF ZONULA OCCLUDENS (TIGHT JUNCTION) BY HYPERGRAVITY DURING DEVELOPMENTAL PERIOD OF NEWBORN RAT BRAIN

Abstract

The realization of a long lasting dream of living in outer space and the potential use of hypergravity for the treatment of ailments such as osteoporosis prompted extensive research on the effects of microgravity and hypergravity on the organisms and to shed light to the mechanisms associated with these. Zonula occludens, ZO also known as tight junctions in the brain are particularly important since they have a role in the formation of blood-brain barrier (BBB). In this study we examined the effects of hypergravity (2G) and rotation on zonula occludens. (TJ). Ninety newborn Wistar albino rats are used in the study. Rotation group were subjected to centrifugation that is equivalent to the gravitational force (G) while hypergravity group underwent centrifugation that was twice as much as the gravity for 6 hours a day. Under ether anesthesia, rats in each subgroup were perfused with 10% formalin, decapitated and the brains were removed. Paraffin sections were immunohistochemically stained with ZO-1 and occludin dyes and examined under a light microscope. ZO-1 and occludin proteins appeared normally during the course of the development. Light microscopic examination did not reveal any differences between the control group and rotation hypergravity groups with regard to the appearance or the distribution of these proteins.

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Primary Language

Turkish

Subjects

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Journal Section

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Authors

M. İbrahim Tuğlu

Enis Cezayirli

Tuncay Varol

Ertuğrul Tatlısumak

Seda Vatansever

Publication Date

September 1, 2004

Submission Date

September 1, 2004

Acceptance Date

-

Published in Issue

Year 2004 Volume: 43 Number: 3

IZ

https://izlik.org/JA97CG67JH

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1.M. İbrahim Tuğlu, Enis Cezayirli, Tuncay Varol, Ertuğrul Tatlısumak, Seda Vatansever. YENİDOĞAN RAT BEYNİNDE GELİŞİM DÖNEMİNDE YÜKSEK YERÇEKİMİNE BAĞLI ZONULA OCCLUDENS (TIGHT JUNCTION) YAPISAL DEĞİŞİKLİKLERİNİN İNCELENMESİ. EJM [Internet]. 2004 Sep. 1;43(3):151-7. Available from: https://izlik.org/JA97CG67JH

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