EVALUATION OF P53 AND Ki67 EXPRESSION IMMUNOHISTOCHEMICALLY IN PANCREATIC DUCTAL ADENOCARCINOMA AND PANCREATIC INTRAEPITHELIAL NEOPLASIAS

Volume: 45 Number: 2 June 1, 2006
  • Deniz Nart
  • Yeşim Ertan
  • Metin Çiriş
  • Murat Zeytunlu
  • Gül Yüce
  • Yıldıray Yüzer
  • Ahmet Çoker
  • Funda Yılmaz
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EVALUATION OF P53 AND Ki67 EXPRESSION IMMUNOHISTOCHEMICALLY IN PANCREATIC DUCTAL ADENOCARCINOMA AND PANCREATIC INTRAEPITHELIAL NEOPLASIAS

Abstract

Pancreatic ductal adenocarcinoma (PDA) is thought to arise from noninvasive dysplastic intraductal lesions, named pancreatic intraepithelial neoplasias (PanIN). Morphologic and genetic observations have provided strong evidence that PanINs can be the precursors of PDA. We evaluated 21 patients with diagnosis of PDA. The histologic sections, harboring both PanIN and PDA were identified. PanIN lesions were counted, graded and their localization was evaluated. We examined also the expression of Ki67 and p53, immunohistochemically. Interlobular location of PanIN lesions (58.20%) were more intense than intralobular location (41.80%). PanIN 2 and 3 within interlobular ducts were significantly higher than intralobular ducts (p=0.0026 ve p=0.006,respectively). P53 and Ki67 expression in PanIN were lower than PDA, statistically (p=0.0045 ve p=0.0002, respectively). P53 tumor suppressor gene and Ki67, proliferation marker in PanINs can provide additional support for the hypothesis that these lesions represent progression with the potential for invasion.

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Primary Language

Turkish

Subjects

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Journal Section

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Authors

Deniz Nart

Yeşim Ertan

Metin Çiriş

Murat Zeytunlu

Gül Yüce

Yıldıray Yüzer

Ahmet Çoker

Funda Yılmaz

Publication Date

June 1, 2006

Submission Date

June 1, 2006

Acceptance Date

-

Published in Issue

Year 2006 Volume: 45 Number: 2

IZ

https://izlik.org/JA98UL59EB

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1.Deniz Nart, Yeşim Ertan, Metin Çiriş, Murat Zeytunlu, Gül Yüce, Yıldıray Yüzer, Ahmet Çoker, Funda Yılmaz. PANKREATİK ADENOKARSİNOM VE PANKREATİK İNTRAEPİTELYAL NEOPLAZİLERDE İMMUNOHİSTOKİMYASAL OLARAK p53 VE Ki 67 EKSPRESYONUNUN DEĞERLENDİRİLMESİ. EJM [Internet]. 2006 Jun. 1;45(2):77-82. Available from: https://izlik.org/JA98UL59EB

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