HEPATOSELLÜLER KARSİNOMLARDA SOMATOSTATİN RESEPTÖR 1 EKSPRESYONU

Gül Yüce; Deniz Nart; Yıldıray Yüzer; Ömer Özütemiz; Galip Ersöz; Ulus Akarca; Yücel Batur

EN TR

SOMATOSTATIN RECEPTOR 1 EXPRESSION IN HEPATOCELLULAR CARCINOMA

Abstract

Somatostatin is a neuropeptide that inhibits cell proliferation. Although somatostatin analogs are used widely in hepatocellular carcinoma treatment, knowledge about malign hepatocyte receptor expression is not sufficient. Somatostatin receptor 1 (SSTR 1) was applied by immunohistochemistry in paraffin sections of 53 hepatocellular carcinoma cases. No correlation was found between morphological parameters and SSTR 1 positivity. Interestingly a close negative relationship was observed between Ki67 and SSTR1. In our study, exhibition of negative correlation between SSTR1 expression and Ki67 proliferation marker supports antiproliferative effect of somatostatin analogs.

Keywords

Hepatocellular carcinoma, somatostatin receptor 1, SSTR 1, immunohistochemistry

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Gül Yüce

Deniz Nart

Yıldıray Yüzer

Ömer Özütemiz

Galip Ersöz

Ulus Akarca

Yücel Batur

Publication Date

June 1, 2006

Submission Date

June 1, 2006

Acceptance Date

-

Published in Issue

Year 2006 Volume: 45 Number: 2

IZ

https://izlik.org/JA92AK77EE

Cite

RIS / Bibtex

Vancouver

1.Gül Yüce, Deniz Nart, Yıldıray Yüzer, Ömer Özütemiz, Galip Ersöz, Ulus Akarca, Yücel Batur. HEPATOSELLÜLER KARSİNOMLARDA SOMATOSTATİN RESEPTÖR 1 EKSPRESYONU. EJM [Internet]. 2006 Jun. 1;45(2):115-20. Available from: https://izlik.org/JA92AK77EE

SOMATOSTATIN RECEPTOR 1 EXPRESSION IN HEPATOCELLULAR CARCINOMA

Abstract

Keywords