THE PREVALENCE OF FACTOR V LEIDEN GENE MUTATION ANALYSIS OF DONOR AND RECIPIENT AT THE ORGAN TRANSPLANTATION CENTER OF EGE UNIVERSITY

Volume: 45 Number: 3 September 1, 2006
  • Zuhal Eroğlu
  • Çığır Biray Avcı
  • Murat Kılıç
  • Buket Kosova
  • Erdal Özen
  • Cumhur Gündüz
  • Nejat Topçuoğlu
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THE PREVALENCE OF FACTOR V LEIDEN GENE MUTATION ANALYSIS OF DONOR AND RECIPIENT AT THE ORGAN TRANSPLANTATION CENTER OF EGE UNIVERSITY

Abstract

Liver transplantation has become a routine procedure for the treatment of end stage of chronic liver disease and acute liver failure. Factor V which is one of the coagulation factors is synthesized by the liver. Defects in coagulation factor genes may lead to the production of abnormal or deficient proteins that constellate risk factors for the development of deep-vein thrombosis. Acquired Active protein C resistance is the most encountered coagulation abnormality and in 90–95 % of cases and it is caused by a point mutation in the factor V gene. The factor V Leiden mutation is genotyped for a single base-pair change (G1691A). Patients who develop venous thrombosis after liver transplantation should be screened for thrombophilic abnormalities. Deep-vein thrombosis occurs approximately 2.7% of patients after liver transplantation. For this reason, FV Leiden mutation has determined in organ donors and recipients. In our study; recipient (191 individuals), donors (693 individuals) totally 884 cases appealed to our department. Genomic DNA of the cases isolated and FV Leiden mutation was determined by Real Time Online PCR. Totally 884 individual, included to our study. The prevalence of the heterozygous mutation was 80 and homozygous mutation was 3. Number of normal genotype was determined 801 individuals. Routine screening for factor V Leiden mutation by polymerase chain reaction, and appropriate pre-operative and post-operative anticoagulation after transplantation might be valuable strategy to prevent tromboembolic complications in transplant recipients.

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Primary Language

Turkish

Subjects

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Journal Section

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Authors

Zuhal Eroğlu

Çığır Biray Avcı

Murat Kılıç

Buket Kosova

Erdal Özen

Cumhur Gündüz

Nejat Topçuoğlu

Publication Date

September 1, 2006

Submission Date

September 1, 2006

Acceptance Date

-

Published in Issue

Year 2006 Volume: 45 Number: 3

IZ

https://izlik.org/JA96TH44HC

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1.Zuhal Eroğlu, Çığır Biray Avcı, Murat Kılıç, Buket Kosova, Erdal Özen, Cumhur Gündüz, Nejat Topçuoğlu. EGE ÜNİVERSİTESİ ORGAN NAKLİ MERKEZİNDE KARACİĞER TRANSPLANTASYONU ALICI VE DONÖRLERİNDEKİ FAKTÖR V LEİDEN GEN MUTASYONUNUN PREVALANSI. EJM [Internet]. 2006 Sep. 1;45(3):185-9. Available from: https://izlik.org/JA96TH44HC

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