THE EFFECT OF A MONOAMINE OXIDASE (MAO)-B INHIBITOR; PARGYLINE ON OXIDANT STRESS/ ANTIOXIDANT STATUS IN AGING RAT TISSUES

Volume: 46 Number: 1 March 1, 2007
  • Gülinnaz Alper
  • Mert Özgönül
  • Ferhan Sağın
  • Seda V. İrer
  • Biltan Ersöz
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THE EFFECT OF A MONOAMINE OXIDASE (MAO)-B INHIBITOR; PARGYLINE ON OXIDANT STRESS/ ANTIOXIDANT STATUS IN AGING RAT TISSUES

Abstract

Aging is the accumulation of changes responsible for the progressive increases in the chance of disease and death. Among the theories proposed to account for this process; “the free radical theory of aging” has been widely accepted. Meanwhile, the increase in catecholamine metabolism is another physiological alteration related to this process, predisposing the organism to enhanced H2O2 production. The aim of this study was to assess the role of oxidant stress and antioxidant status in the aging process by determining MAO activity, lipid peroxidation products (LPPs) – diene conjugates and MDA levels, antioxidant enzymes – SOD and CAT in young and aging rat tissues and to investigate the effect of pargyline, a MAO-B inhibitor in reducing oxidant stress via inhibition of MAO. In general, significant increases in tissue MAO activitiy and LPPs were noted in aging rats, positively correlated wıth each other and significantly decreased after pargyline administration. In conclusion, the inhibition of MAO activity may attenuate the process of aging by reducing increased lipid peroxidation and concomitant oxidant stress.

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Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Gülinnaz Alper

Mert Özgönül

Ferhan Sağın

Seda V. İrer

Biltan Ersöz

Publication Date

March 1, 2007

Submission Date

March 1, 2007

Acceptance Date

-

Published in Issue

Year 1970 Volume: 46 Number: 1

IZ

https://izlik.org/JA96LK97HD

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1.Gülinnaz Alper, Mert Özgönül, Ferhan Sağın, Seda V. İrer, Biltan Ersöz. YAŞLANAN SIÇAN DOKULARINDA OKSİDAN STRES VE ANTİOKSİDAN SAVUNMA DURUMUNA MONOAMİNOKSİDAZ (MAO)-B İNHİBİTÖRÜ PARJİLİNİN ETKİSİ. EJM [Internet]. 2007 Mar. 1;46(1):27-32. Available from: https://izlik.org/JA96LK97HD

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