Investigation of hepatotoxic effect of nimesulide on rats

Volume: 47 Number: 1 March 1, 2008
  • Özer S
  • Karadağlı F
  • Ortaç R
  • Lermioğlu F
Ege Journal of Medicine Cover
Ege Journal of Medicine
PDF Download
EN TR

Investigation of hepatotoxic effect of nimesulide on rats

Abstract

Aim: Several cases of severe liver injury have been reported following the administration of nimesulide. The exact mechanism of hepatotoxic effect of nimesulide is yet to be clarified. The reactive metabolites that induce oxidative stress, has been suggested to be responsible for the liver damage as a result of the drug administration. However, it is well known that nimesulide has antioxidant activity as a consequence of its free radical scavenging activity. In this study, we aimed to investigate the hepatotoxic effect of nimesulide, the relationship of drug-induced liver damage and oxidative stress as well as antioxidant enzyme activities. Material and Method: Adult female rats were treated with nimesulide at doses of 2X2.5 (Group I) or 2X5.0 mg/kg/day (Group II) by intragastric gavage for 14 days. Control rats (Group K) received only 0.5 % carboxymethyl cellulose (CMC). Hepatotoxicity was monitored by histopathological evaluation of the livers and by measuring plasma malondialdehyde (MDA) level and serum biomarkers. Erythrocyte antioxidant enzymes activities were determined. Results: Nimesulide treatment caused significant increases in plasma MDA levels in both groups. Serum AST activities in Group I, and serum ALP activities in both nimesulide-treated groups, were significantly higher compared to Group K. In regard to antioxidant enzymes, a significant increase in the activity of catalase was observed in Group II. Histopathological examination of livers revealed mild to moderate damage, particularly in the rats treated with high dose of nimesulide. Conclusion: Our results indicate the hepatotoxicity potential of nimesulide and that oxidative stress might play a role for the development of liver injury in female rats.

Keywords

Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Özer S

Karadağlı F

Ortaç R

Lermioğlu F

Publication Date

March 1, 2008

Submission Date

March 1, 2008

Acceptance Date

-

Published in Issue

Year 2008 Volume: 47 Number: 1

IZ

https://izlik.org/JA89WB44PU

Cite

RIS / Bibtex
Vancouver
1.Özer S, Karadağlı F, Ortaç R, Lermioğlu F. Nimesulidin hepatotoksik etkisinin sıçanlarda araştırılması. EJM [Internet]. 2008 Mar. 1;47(1):1-5. Available from: https://izlik.org/JA89WB44PU

Ege Journal of Medicine enables the sharing of articles according to the Attribution-Non-Commercial-Share Alike 4.0 International (CC BY-NC-SA 4.0) license.