Nimesulidin hepatotoksik etkisinin sıçanlarda araştırılması

Cilt: 47 Sayı: 1 1 Mart 2008
  • Özer S
  • Karadağlı F
  • Ortaç R
  • Lermioğlu F
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Investigation of hepatotoxic effect of nimesulide on rats

Abstract

Aim: Several cases of severe liver injury have been reported following the administration of nimesulide. The exact mechanism of hepatotoxic effect of nimesulide is yet to be clarified. The reactive metabolites that induce oxidative stress, has been suggested to be responsible for the liver damage as a result of the drug administration. However, it is well known that nimesulide has antioxidant activity as a consequence of its free radical scavenging activity. In this study, we aimed to investigate the hepatotoxic effect of nimesulide, the relationship of drug-induced liver damage and oxidative stress as well as antioxidant enzyme activities. Material and Method: Adult female rats were treated with nimesulide at doses of 2X2.5 (Group I) or 2X5.0 mg/kg/day (Group II) by intragastric gavage for 14 days. Control rats (Group K) received only 0.5 % carboxymethyl cellulose (CMC). Hepatotoxicity was monitored by histopathological evaluation of the livers and by measuring plasma malondialdehyde (MDA) level and serum biomarkers. Erythrocyte antioxidant enzymes activities were determined. Results: Nimesulide treatment caused significant increases in plasma MDA levels in both groups. Serum AST activities in Group I, and serum ALP activities in both nimesulide-treated groups, were significantly higher compared to Group K. In regard to antioxidant enzymes, a significant increase in the activity of catalase was observed in Group II. Histopathological examination of livers revealed mild to moderate damage, particularly in the rats treated with high dose of nimesulide. Conclusion: Our results indicate the hepatotoxicity potential of nimesulide and that oxidative stress might play a role for the development of liver injury in female rats.

Keywords

Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

-

Yazarlar

Özer S

Karadağlı F

Ortaç R

Lermioğlu F

Yayımlanma Tarihi

1 Mart 2008

Gönderilme Tarihi

1 Mart 2008

Kabul Tarihi

-

Yayımlandığı Sayı

Yıl 2008 Cilt: 47 Sayı: 1

IZ

https://izlik.org/JA89WB44PU

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RIS / Bibtex
Vancouver
1.Özer S, Karadağlı F, Ortaç R, Lermioğlu F. Nimesulidin hepatotoksik etkisinin sıçanlarda araştırılması. ETD [Internet]. 01 Mart 2008;47(1):1-5. Erişim adresi: https://izlik.org/JA89WB44PU

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