Evaluation of the polymorphisms of genes affecting thrombosis throughout sepsis in children

Volume: 48 Number: 2 June 1, 2009
  • Cogulu O
  • Onay H
  • Gunduz C
  • Ekmekci A
  • Atlihan F
  • Ozkinay F
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Evaluation of the polymorphisms of genes affecting thrombosis throughout sepsis in children

Abstract

Aim: Since the clinical course of sepsis exhibits individual variance, its genetic background and the polymorphisms found in the genes which may be responsible for the predisposition to sepsis have been investigated. The interaction between coagulation and sepsis has directed researchers to investigate the genetic polymorphisms of those factors. We aimed to determine the polymorphisms of Factor V Leiden, Factor V 1299, prothrombin, Factor XIII, beta-fibrinogen, plasminogen activator inhibitor 1, glycoprotein III, MTHFR, Apo E in children with sepsis and septic shock. Material and Methods: Ninety-two children with sepsis and ninety-two healthy children were included into the study by using a reverse-hybridization assay. Among the study group 20 cases developed septic shock (10 of nonsurvivors was in the septic shock group, 4 in the sepsis group). Results: Among the sepsis group, a total of 16 cases had (17.4 %) positive blood cultures. The microorganisms were Pseudomonas aeruginosa in 7 cases (43.7 %), Klebsiella pneumoniae in 3 (18.7 %), Eschherichia coli in 2 (12.5 %), Streptococcus pneumonia in 2 (12.5 %), Enterococcus faecalis in 1 (6.3 %) and Candida albicans in 1 (6.3 %). No statistically significant difference associated with all the polymorphisms between the groups of sepsis, septic shock and nonsurvivors compared to healthy group was achieved. Conclusion: The polymorphisms investigated in the proteins having a role in the thrombosis process were not found to have a significant effect on the incidence of developing sepsis or outcome of sepsis in children.

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Primary Language

Turkish

Subjects

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Journal Section

-

Authors

Cogulu O

Onay H

Gunduz C

Ekmekci A

Atlihan F

Ozkinay F

Publication Date

June 1, 2009

Submission Date

June 1, 2009

Acceptance Date

-

Published in Issue

Year 2009 Volume: 48 Number: 2

IZ

https://izlik.org/JA97KM27GG

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RIS / Bibtex
Vancouver
1.Cogulu O, Onay H, Gunduz C, Ekmekci A, Atlihan F, Ozkinay F. Sepsisli çocuklarda trombozu etkileyen genlerdeki polimorfizmlerin değerlendirilmesi. EJM [Internet]. 2009 Jun. 1;48(2):77-83. Available from: https://izlik.org/JA97KM27GG

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